Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19

Coagulation dysfunction and inflammatory status were compared between diabetic and non-diabetic COVID-19 patients. The standardized mean difference (SMD) and its 95% confidence interval (CI) was computed for the difference of inflammatory and hypercoagulability markers. The levels of serum ferritin...

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Autores principales: Varikasuvu, Seshadri Reddy, Varshney, Saurabh, Dutt, Naveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474490/
https://www.ncbi.nlm.nih.gov/pubmed/32889620
http://dx.doi.org/10.1007/s11239-020-02270-w
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author Varikasuvu, Seshadri Reddy
Varshney, Saurabh
Dutt, Naveen
author_facet Varikasuvu, Seshadri Reddy
Varshney, Saurabh
Dutt, Naveen
author_sort Varikasuvu, Seshadri Reddy
collection PubMed
description Coagulation dysfunction and inflammatory status were compared between diabetic and non-diabetic COVID-19 patients. The standardized mean difference (SMD) and its 95% confidence interval (CI) was computed for the difference of inflammatory and hypercoagulability markers. The levels of serum ferritin (standardized mean difference-SMD: 0.47, CI 0.17–0.77, p = 0.002), C-reactive protein (SMD = 0.53, CI 0.20–0.86, p = 0.002), interleukin-6 (SMD = 0.31, CI 0.09–0.52, p = 0.005), fibrinogen (SMD = 0.31, CI 0.09–0.54, p = 0.007) and D-dimers (SMD = 0.54, CI 0.16–0.91, p = 0.005) were significantly higher in diabetic COVID-19 cases as compared to non-diabetic COVID-19 patients, suggesting more susceptibility of diabetic COVID-19 patients to coagulation dysfunction and inflammatory storm.
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spelling pubmed-74744902020-09-08 Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19 Varikasuvu, Seshadri Reddy Varshney, Saurabh Dutt, Naveen J Thromb Thrombolysis Research Letter Coagulation dysfunction and inflammatory status were compared between diabetic and non-diabetic COVID-19 patients. The standardized mean difference (SMD) and its 95% confidence interval (CI) was computed for the difference of inflammatory and hypercoagulability markers. The levels of serum ferritin (standardized mean difference-SMD: 0.47, CI 0.17–0.77, p = 0.002), C-reactive protein (SMD = 0.53, CI 0.20–0.86, p = 0.002), interleukin-6 (SMD = 0.31, CI 0.09–0.52, p = 0.005), fibrinogen (SMD = 0.31, CI 0.09–0.54, p = 0.007) and D-dimers (SMD = 0.54, CI 0.16–0.91, p = 0.005) were significantly higher in diabetic COVID-19 cases as compared to non-diabetic COVID-19 patients, suggesting more susceptibility of diabetic COVID-19 patients to coagulation dysfunction and inflammatory storm. Springer US 2020-09-05 2021 /pmc/articles/PMC7474490/ /pubmed/32889620 http://dx.doi.org/10.1007/s11239-020-02270-w Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Letter
Varikasuvu, Seshadri Reddy
Varshney, Saurabh
Dutt, Naveen
Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19
title Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19
title_full Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19
title_fullStr Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19
title_full_unstemmed Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19
title_short Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19
title_sort markers of coagulation dysfunction and inflammation in diabetic and non-diabetic covid-19
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474490/
https://www.ncbi.nlm.nih.gov/pubmed/32889620
http://dx.doi.org/10.1007/s11239-020-02270-w
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