Selenoprotein N is an endoplasmic reticulum calcium sensor that links luminal calcium levels to a redox activity

The endoplasmic reticulum (ER) is the reservoir for calcium in cells. Luminal calcium levels are determined by calcium-sensing proteins that trigger calcium dynamics in response to calcium fluctuations. Here we report that Selenoprotein N (SEPN1) is a type II transmembrane protein that senses ER cal...

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Detalles Bibliográficos
Autores principales: Chernorudskiy, Alexander, Varone, Ersilia, Colombo, Sara Francesca, Fumagalli, Stefano, Cagnotto, Alfredo, Cattaneo, Angela, Briens, Mickael, Baltzinger, Mireille, Kuhn, Lauriane, Bachi, Angela, Berardi, Andrea, Salmona, Mario, Musco, Giovanna, Borgese, Nica, Lescure, Alain, Zito, Ester
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474598/
https://www.ncbi.nlm.nih.gov/pubmed/32817544
http://dx.doi.org/10.1073/pnas.2003847117

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