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Immune signatures of prodromal multiple sclerosis in monozygotic twins
The tremendous heterogeneity of the human population presents a major obstacle in understanding how autoimmune diseases like multiple sclerosis (MS) contribute to variations in human peripheral immune signatures. To minimize heterogeneity, we made use of a unique cohort of 43 monozygotic twin pairs...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474627/ https://www.ncbi.nlm.nih.gov/pubmed/32817525 http://dx.doi.org/10.1073/pnas.2003339117 |
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author | Gerdes, Lisa Ann Janoschka, Claudia Eveslage, Maria Mannig, Bianca Wirth, Timo Schulte-Mecklenbeck, Andreas Lauks, Sarah Glau, Laura Gross, Catharina C. Tolosa, Eva Flierl-Hecht, Andrea Ertl-Wagner, Birgit Barkhof, Frederik Meuth, Sven G. Kümpfel, Tania Wiendl, Heinz Hohlfeld, Reinhard Klotz, Luisa |
author_facet | Gerdes, Lisa Ann Janoschka, Claudia Eveslage, Maria Mannig, Bianca Wirth, Timo Schulte-Mecklenbeck, Andreas Lauks, Sarah Glau, Laura Gross, Catharina C. Tolosa, Eva Flierl-Hecht, Andrea Ertl-Wagner, Birgit Barkhof, Frederik Meuth, Sven G. Kümpfel, Tania Wiendl, Heinz Hohlfeld, Reinhard Klotz, Luisa |
author_sort | Gerdes, Lisa Ann |
collection | PubMed |
description | The tremendous heterogeneity of the human population presents a major obstacle in understanding how autoimmune diseases like multiple sclerosis (MS) contribute to variations in human peripheral immune signatures. To minimize heterogeneity, we made use of a unique cohort of 43 monozygotic twin pairs clinically discordant for MS and searched for disease-related peripheral immune signatures in a systems biology approach covering a broad range of adaptive and innate immune populations on the protein level. Despite disease discordance, the immune signatures of MS-affected and unaffected cotwins were remarkably similar. Twinship alone contributed 56% of the immune variation, whereas MS explained 1 to 2% of the immune variance. Notably, distinct traits in CD4(+) effector T cell subsets emerged when we focused on a subgroup of twins with signs of subclinical, prodromal MS in the clinically healthy cotwin. Some of these early-disease immune traits were confirmed in a second independent cohort of untreated early relapsing-remitting MS patients. Early involvement of effector T cell subsets thus points to a key role of T cells in MS disease initiation. |
format | Online Article Text |
id | pubmed-7474627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-74746272020-09-18 Immune signatures of prodromal multiple sclerosis in monozygotic twins Gerdes, Lisa Ann Janoschka, Claudia Eveslage, Maria Mannig, Bianca Wirth, Timo Schulte-Mecklenbeck, Andreas Lauks, Sarah Glau, Laura Gross, Catharina C. Tolosa, Eva Flierl-Hecht, Andrea Ertl-Wagner, Birgit Barkhof, Frederik Meuth, Sven G. Kümpfel, Tania Wiendl, Heinz Hohlfeld, Reinhard Klotz, Luisa Proc Natl Acad Sci U S A Biological Sciences The tremendous heterogeneity of the human population presents a major obstacle in understanding how autoimmune diseases like multiple sclerosis (MS) contribute to variations in human peripheral immune signatures. To minimize heterogeneity, we made use of a unique cohort of 43 monozygotic twin pairs clinically discordant for MS and searched for disease-related peripheral immune signatures in a systems biology approach covering a broad range of adaptive and innate immune populations on the protein level. Despite disease discordance, the immune signatures of MS-affected and unaffected cotwins were remarkably similar. Twinship alone contributed 56% of the immune variation, whereas MS explained 1 to 2% of the immune variance. Notably, distinct traits in CD4(+) effector T cell subsets emerged when we focused on a subgroup of twins with signs of subclinical, prodromal MS in the clinically healthy cotwin. Some of these early-disease immune traits were confirmed in a second independent cohort of untreated early relapsing-remitting MS patients. Early involvement of effector T cell subsets thus points to a key role of T cells in MS disease initiation. National Academy of Sciences 2020-09-01 2020-08-17 /pmc/articles/PMC7474627/ /pubmed/32817525 http://dx.doi.org/10.1073/pnas.2003339117 Text en Copyright © 2020 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Gerdes, Lisa Ann Janoschka, Claudia Eveslage, Maria Mannig, Bianca Wirth, Timo Schulte-Mecklenbeck, Andreas Lauks, Sarah Glau, Laura Gross, Catharina C. Tolosa, Eva Flierl-Hecht, Andrea Ertl-Wagner, Birgit Barkhof, Frederik Meuth, Sven G. Kümpfel, Tania Wiendl, Heinz Hohlfeld, Reinhard Klotz, Luisa Immune signatures of prodromal multiple sclerosis in monozygotic twins |
title | Immune signatures of prodromal multiple sclerosis in monozygotic twins |
title_full | Immune signatures of prodromal multiple sclerosis in monozygotic twins |
title_fullStr | Immune signatures of prodromal multiple sclerosis in monozygotic twins |
title_full_unstemmed | Immune signatures of prodromal multiple sclerosis in monozygotic twins |
title_short | Immune signatures of prodromal multiple sclerosis in monozygotic twins |
title_sort | immune signatures of prodromal multiple sclerosis in monozygotic twins |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474627/ https://www.ncbi.nlm.nih.gov/pubmed/32817525 http://dx.doi.org/10.1073/pnas.2003339117 |
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