Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid

Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from...

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Detalles Bibliográficos
Autores principales: Johansson, Viktoria, Erhardt, Sophie, Engberg, Göran, Kegel, Magdalena, Bhat, Maria, Schwieler, Lilly, Blennow, Kaj, Zetterberg, Henrik, Cannon, Tyrone D., Wetterberg, Lennart, Hultman, Christina M., Landén, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474706/
https://www.ncbi.nlm.nih.gov/pubmed/31302732
http://dx.doi.org/10.1007/s00406-019-01042-9
Descripción
Sumario:Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00406-019-01042-9) contains supplementary material, which is available to authorized users.

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