Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C

The development of hepatocellular carcinoma (HCC) after a sustained virologic response (SVR) due to interferon (IFN) therapy for hepatitis C virus infection remains a serious problem. We herein report 2 cases of HCC that developed more than 20 years after SVR with IFN therapy for chronic hepatitis C...

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Detalles Bibliográficos
Autores principales: Takata, Kazuhide, Ishii, Fuminori, Uchida, Yotaro, Fukuda, Hiromi, Yamauchi, Ryo, Umeda, Kaoru, Tsuchiya, Naoaki, Tanaka, Takashi, Yokoyama, Keiji, Morihara, Daisuke, Takeyama, Yasuaki, Shakado, Satoshi, Sakisaka, Shotaro, Hirai, Fumihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474997/
https://www.ncbi.nlm.nih.gov/pubmed/32350199
http://dx.doi.org/10.2169/internalmedicine.4479-20
Descripción
Sumario:The development of hepatocellular carcinoma (HCC) after a sustained virologic response (SVR) due to interferon (IFN) therapy for hepatitis C virus infection remains a serious problem. We herein report 2 cases of HCC that developed more than 20 years after SVR with IFN therapy for chronic hepatitis C. The patients were 89- and 72-year-old men with HCC that developed 24-25 years after an SVR with IFN therapy. These patients regularly underwent imaging examinations; therefore, the HCC was detected in the early stage, when it was still curable. Both cases suggest that long-term surveillance after an SVR is effective for the detection of HCC, and radical treatment is possible.

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