Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C

The development of hepatocellular carcinoma (HCC) after a sustained virologic response (SVR) due to interferon (IFN) therapy for hepatitis C virus infection remains a serious problem. We herein report 2 cases of HCC that developed more than 20 years after SVR with IFN therapy for chronic hepatitis C...

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Autores principales: Takata, Kazuhide, Ishii, Fuminori, Uchida, Yotaro, Fukuda, Hiromi, Yamauchi, Ryo, Umeda, Kaoru, Tsuchiya, Naoaki, Tanaka, Takashi, Yokoyama, Keiji, Morihara, Daisuke, Takeyama, Yasuaki, Shakado, Satoshi, Sakisaka, Shotaro, Hirai, Fumihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474997/
https://www.ncbi.nlm.nih.gov/pubmed/32350199
http://dx.doi.org/10.2169/internalmedicine.4479-20
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author Takata, Kazuhide
Ishii, Fuminori
Uchida, Yotaro
Fukuda, Hiromi
Yamauchi, Ryo
Umeda, Kaoru
Tsuchiya, Naoaki
Tanaka, Takashi
Yokoyama, Keiji
Morihara, Daisuke
Takeyama, Yasuaki
Shakado, Satoshi
Sakisaka, Shotaro
Hirai, Fumihito
author_facet Takata, Kazuhide
Ishii, Fuminori
Uchida, Yotaro
Fukuda, Hiromi
Yamauchi, Ryo
Umeda, Kaoru
Tsuchiya, Naoaki
Tanaka, Takashi
Yokoyama, Keiji
Morihara, Daisuke
Takeyama, Yasuaki
Shakado, Satoshi
Sakisaka, Shotaro
Hirai, Fumihito
author_sort Takata, Kazuhide
collection PubMed
description The development of hepatocellular carcinoma (HCC) after a sustained virologic response (SVR) due to interferon (IFN) therapy for hepatitis C virus infection remains a serious problem. We herein report 2 cases of HCC that developed more than 20 years after SVR with IFN therapy for chronic hepatitis C. The patients were 89- and 72-year-old men with HCC that developed 24-25 years after an SVR with IFN therapy. These patients regularly underwent imaging examinations; therefore, the HCC was detected in the early stage, when it was still curable. Both cases suggest that long-term surveillance after an SVR is effective for the detection of HCC, and radical treatment is possible.
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spelling pubmed-74749972020-09-18 Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C Takata, Kazuhide Ishii, Fuminori Uchida, Yotaro Fukuda, Hiromi Yamauchi, Ryo Umeda, Kaoru Tsuchiya, Naoaki Tanaka, Takashi Yokoyama, Keiji Morihara, Daisuke Takeyama, Yasuaki Shakado, Satoshi Sakisaka, Shotaro Hirai, Fumihito Intern Med Case Report The development of hepatocellular carcinoma (HCC) after a sustained virologic response (SVR) due to interferon (IFN) therapy for hepatitis C virus infection remains a serious problem. We herein report 2 cases of HCC that developed more than 20 years after SVR with IFN therapy for chronic hepatitis C. The patients were 89- and 72-year-old men with HCC that developed 24-25 years after an SVR with IFN therapy. These patients regularly underwent imaging examinations; therefore, the HCC was detected in the early stage, when it was still curable. Both cases suggest that long-term surveillance after an SVR is effective for the detection of HCC, and radical treatment is possible. The Japanese Society of Internal Medicine 2020-04-30 2020-08-01 /pmc/articles/PMC7474997/ /pubmed/32350199 http://dx.doi.org/10.2169/internalmedicine.4479-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takata, Kazuhide
Ishii, Fuminori
Uchida, Yotaro
Fukuda, Hiromi
Yamauchi, Ryo
Umeda, Kaoru
Tsuchiya, Naoaki
Tanaka, Takashi
Yokoyama, Keiji
Morihara, Daisuke
Takeyama, Yasuaki
Shakado, Satoshi
Sakisaka, Shotaro
Hirai, Fumihito
Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C
title Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C
title_full Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C
title_fullStr Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C
title_full_unstemmed Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C
title_short Two Cases of Hepatocellular Carcinoma Arising Over 20 Years after a Sustained Virologic Response Following Interferon Therapy for Chronic Hepatitis C
title_sort two cases of hepatocellular carcinoma arising over 20 years after a sustained virologic response following interferon therapy for chronic hepatitis c
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474997/
https://www.ncbi.nlm.nih.gov/pubmed/32350199
http://dx.doi.org/10.2169/internalmedicine.4479-20
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