Cargando…

Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months

BACKGROUND: Bariatric surgery is an effective treatment for morbid obesity and glycaemic dysfunction. OBJECTIVES: The aim of the work was to examine both the static and dynamic changes of glucose-insulin homeostasis and incretin hormone response following sleeve gastrectomy (SG) in a sample of 55 pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Prior, S. L., Churm, R., Min, T., Dunseath, G. J., Barry, J. D., Stephens, J. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475060/
https://www.ncbi.nlm.nih.gov/pubmed/32067166
http://dx.doi.org/10.1007/s11695-020-04457-9
_version_ 1783579444613480448
author Prior, S. L.
Churm, R.
Min, T.
Dunseath, G. J.
Barry, J. D.
Stephens, J. W.
author_facet Prior, S. L.
Churm, R.
Min, T.
Dunseath, G. J.
Barry, J. D.
Stephens, J. W.
author_sort Prior, S. L.
collection PubMed
description BACKGROUND: Bariatric surgery is an effective treatment for morbid obesity and glycaemic dysfunction. OBJECTIVES: The aim of the work was to examine both the static and dynamic changes of glucose-insulin homeostasis and incretin hormone response following sleeve gastrectomy (SG) in a sample of 55 participants preoperatively and 1 month and 6 months postoperatively. The focus was on a sample of patients with impaired glucose tolerance and type 2 diabetes (T2D). SETTING: Morriston Hospital, UK. METHODS: Prospective study comprising of 55 participants with impaired glucose homeostasis and T2D undergoing SG (mean body mass index [BMI] 50.4 kg/m(2), mean glycated haemoglobin [A1C] 7.4%). Serial measurements of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic hormone (GIP) were performed during oral glucose tolerance testing preoperatively and 1 and 6 months postoperatively. Areas under the curve (AUC) were examined at 30, 60, and 120 min. RESULTS: We observed significant improvements in measures of obesity, as well as static and dynamic measures of glucose, insulin, C-peptide and HOMA. Furthermore, significant increases in GLP-1 response as early as 6 months postoperatively were also seen. CONCLUSIONS: To our knowledge, no study has examined the detailed dynamic changes in glucose and insulin homeostasis in this number of participants undergoing SG in relation to incretin hormones GIP and GLP-1. This current study supports the role of SG for the treatment of obesity-related glucose dysregulation.
format Online
Article
Text
id pubmed-7475060
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-74750602020-09-16 Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months Prior, S. L. Churm, R. Min, T. Dunseath, G. J. Barry, J. D. Stephens, J. W. Obes Surg Original Contributions BACKGROUND: Bariatric surgery is an effective treatment for morbid obesity and glycaemic dysfunction. OBJECTIVES: The aim of the work was to examine both the static and dynamic changes of glucose-insulin homeostasis and incretin hormone response following sleeve gastrectomy (SG) in a sample of 55 participants preoperatively and 1 month and 6 months postoperatively. The focus was on a sample of patients with impaired glucose tolerance and type 2 diabetes (T2D). SETTING: Morriston Hospital, UK. METHODS: Prospective study comprising of 55 participants with impaired glucose homeostasis and T2D undergoing SG (mean body mass index [BMI] 50.4 kg/m(2), mean glycated haemoglobin [A1C] 7.4%). Serial measurements of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic hormone (GIP) were performed during oral glucose tolerance testing preoperatively and 1 and 6 months postoperatively. Areas under the curve (AUC) were examined at 30, 60, and 120 min. RESULTS: We observed significant improvements in measures of obesity, as well as static and dynamic measures of glucose, insulin, C-peptide and HOMA. Furthermore, significant increases in GLP-1 response as early as 6 months postoperatively were also seen. CONCLUSIONS: To our knowledge, no study has examined the detailed dynamic changes in glucose and insulin homeostasis in this number of participants undergoing SG in relation to incretin hormones GIP and GLP-1. This current study supports the role of SG for the treatment of obesity-related glucose dysregulation. Springer US 2020-02-17 2020 /pmc/articles/PMC7475060/ /pubmed/32067166 http://dx.doi.org/10.1007/s11695-020-04457-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Contributions
Prior, S. L.
Churm, R.
Min, T.
Dunseath, G. J.
Barry, J. D.
Stephens, J. W.
Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
title Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
title_full Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
title_fullStr Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
title_full_unstemmed Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
title_short Temporal Effects of Sleeve Gastrectomy on Glucose-Insulin Homeostasis and Incretin Hormone Response at 1 and 6 Months
title_sort temporal effects of sleeve gastrectomy on glucose-insulin homeostasis and incretin hormone response at 1 and 6 months
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475060/
https://www.ncbi.nlm.nih.gov/pubmed/32067166
http://dx.doi.org/10.1007/s11695-020-04457-9
work_keys_str_mv AT priorsl temporaleffectsofsleevegastrectomyonglucoseinsulinhomeostasisandincretinhormoneresponseat1and6months
AT churmr temporaleffectsofsleevegastrectomyonglucoseinsulinhomeostasisandincretinhormoneresponseat1and6months
AT mint temporaleffectsofsleevegastrectomyonglucoseinsulinhomeostasisandincretinhormoneresponseat1and6months
AT dunseathgj temporaleffectsofsleevegastrectomyonglucoseinsulinhomeostasisandincretinhormoneresponseat1and6months
AT barryjd temporaleffectsofsleevegastrectomyonglucoseinsulinhomeostasisandincretinhormoneresponseat1and6months
AT stephensjw temporaleffectsofsleevegastrectomyonglucoseinsulinhomeostasisandincretinhormoneresponseat1and6months