Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma

BACKGROUND: The co-receptor lymphocyte-activation gene-3 (LAG3, LAG-3, CD223) is a potential target for immune checkpoint inhibition immunotherapies. However, little is known about the biological and clinical significance of LAG3 DNA methylation in melanoma and its microenvironment. METHODS: We eval...

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Detalles Bibliográficos
Autores principales: Fröhlich, Anne, Sirokay, Judith, Fietz, Simon, Vogt, Timo J., Dietrich, Jörn, Zarbl, Romina, Florin, Mike, Kuster, Pia, Saavedra, Gonzalo, Valladolid, Susana Ramírez, Hoffmann, Friederike, Flatz, Lukas, Ring, Sandra S., Golletz, Carsten, Pietsch, Torsten, Strieth, Sebastian, Brossart, Peter, Gielen, Gerrit H., Kristiansen, Glen, Bootz, Friedrich, Landsberg, Jennifer, Dietrich, Dimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475111/
https://www.ncbi.nlm.nih.gov/pubmed/32861198
http://dx.doi.org/10.1016/j.ebiom.2020.102962

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