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Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women
Lower level of insulin-like growth factor-binding protein (IGFBP-1) has been observed in insulin resistance, while higher level of matrix metalloproteinase-8 (MMP-8) has been linked to obesity. The aim here was to study in overweight and obese women, typically manifesting with insulin resistance, wh...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475181/ https://www.ncbi.nlm.nih.gov/pubmed/32923723 http://dx.doi.org/10.1016/j.heliyon.2020.e04788 |
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author | Mokkala, Kati Juhila, Juuso Houttu, Noora Sorsa, Timo Laitinen, Kirsi |
author_facet | Mokkala, Kati Juhila, Juuso Houttu, Noora Sorsa, Timo Laitinen, Kirsi |
author_sort | Mokkala, Kati |
collection | PubMed |
description | Lower level of insulin-like growth factor-binding protein (IGFBP-1) has been observed in insulin resistance, while higher level of matrix metalloproteinase-8 (MMP-8) has been linked to obesity. The aim here was to study in overweight and obese women, typically manifesting with insulin resistance, whether IGFBP-1 and MMP-8 are related to and reflect systemic low-grade inflammation, metabolism and diet. Fasting serum from overweight and obese pregnant women (n = 100) in early pregnancy were analysed for IGFBP-1, phosphorylated IGFBP-1 (phIGFBP-1) and MMP-8. High-sensitivity CRP and GlycA were used as markers for low grade inflammation. GlycA and lipids were quantified using NMR. IGFBP-1 associated negatively with GlycA, evidenced by higher concentrations in the lowest quartile (median 1.53 (IQR 1.45–1.72)) compared to the highest (1.46 (1.39–1.55)) (P = 0.03). Several lipid metabolites, particularly HDL-cholesterol, correlated inversely with phIGFBP-1 (FDR<0.1). Nutritional status and diet contributed to the levels of IGFBP-1, demonstrated as an inverse correlation with maternal weight (Spearman r = -0.205, P = 0.04) and dietary intake of vitamin A (r = -0.253, P = 0.014) and a direct correlation with dietary intake of polyunsaturated fatty acids (Spearman r = 0.222, P = 0.03). MMP-8 correlated inversely with pyridoxine (r = -0.321, P = 0.002) and potassium (r = -0.220, P = 0.033). Maternal serum IGFBP-1 may contribute to maternal lipid metabolism in overweight and obese women during early pregnancy. These findings may be of importance in identification of metabolic disturbances preceding the adverse metabolic outcomes in pregnancy. |
format | Online Article Text |
id | pubmed-7475181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74751812020-09-11 Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women Mokkala, Kati Juhila, Juuso Houttu, Noora Sorsa, Timo Laitinen, Kirsi Heliyon Research Article Lower level of insulin-like growth factor-binding protein (IGFBP-1) has been observed in insulin resistance, while higher level of matrix metalloproteinase-8 (MMP-8) has been linked to obesity. The aim here was to study in overweight and obese women, typically manifesting with insulin resistance, whether IGFBP-1 and MMP-8 are related to and reflect systemic low-grade inflammation, metabolism and diet. Fasting serum from overweight and obese pregnant women (n = 100) in early pregnancy were analysed for IGFBP-1, phosphorylated IGFBP-1 (phIGFBP-1) and MMP-8. High-sensitivity CRP and GlycA were used as markers for low grade inflammation. GlycA and lipids were quantified using NMR. IGFBP-1 associated negatively with GlycA, evidenced by higher concentrations in the lowest quartile (median 1.53 (IQR 1.45–1.72)) compared to the highest (1.46 (1.39–1.55)) (P = 0.03). Several lipid metabolites, particularly HDL-cholesterol, correlated inversely with phIGFBP-1 (FDR<0.1). Nutritional status and diet contributed to the levels of IGFBP-1, demonstrated as an inverse correlation with maternal weight (Spearman r = -0.205, P = 0.04) and dietary intake of vitamin A (r = -0.253, P = 0.014) and a direct correlation with dietary intake of polyunsaturated fatty acids (Spearman r = 0.222, P = 0.03). MMP-8 correlated inversely with pyridoxine (r = -0.321, P = 0.002) and potassium (r = -0.220, P = 0.033). Maternal serum IGFBP-1 may contribute to maternal lipid metabolism in overweight and obese women during early pregnancy. These findings may be of importance in identification of metabolic disturbances preceding the adverse metabolic outcomes in pregnancy. Elsevier 2020-08-30 /pmc/articles/PMC7475181/ /pubmed/32923723 http://dx.doi.org/10.1016/j.heliyon.2020.e04788 Text en © 2020 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Mokkala, Kati Juhila, Juuso Houttu, Noora Sorsa, Timo Laitinen, Kirsi Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women |
title | Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women |
title_full | Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women |
title_fullStr | Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women |
title_full_unstemmed | Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women |
title_short | Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women |
title_sort | early pregnancy serum igfbp-1 relates to lipid profile in overweight and obese women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475181/ https://www.ncbi.nlm.nih.gov/pubmed/32923723 http://dx.doi.org/10.1016/j.heliyon.2020.e04788 |
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