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Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women

Lower level of insulin-like growth factor-binding protein (IGFBP-1) has been observed in insulin resistance, while higher level of matrix metalloproteinase-8 (MMP-8) has been linked to obesity. The aim here was to study in overweight and obese women, typically manifesting with insulin resistance, wh...

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Autores principales: Mokkala, Kati, Juhila, Juuso, Houttu, Noora, Sorsa, Timo, Laitinen, Kirsi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475181/
https://www.ncbi.nlm.nih.gov/pubmed/32923723
http://dx.doi.org/10.1016/j.heliyon.2020.e04788
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author Mokkala, Kati
Juhila, Juuso
Houttu, Noora
Sorsa, Timo
Laitinen, Kirsi
author_facet Mokkala, Kati
Juhila, Juuso
Houttu, Noora
Sorsa, Timo
Laitinen, Kirsi
author_sort Mokkala, Kati
collection PubMed
description Lower level of insulin-like growth factor-binding protein (IGFBP-1) has been observed in insulin resistance, while higher level of matrix metalloproteinase-8 (MMP-8) has been linked to obesity. The aim here was to study in overweight and obese women, typically manifesting with insulin resistance, whether IGFBP-1 and MMP-8 are related to and reflect systemic low-grade inflammation, metabolism and diet. Fasting serum from overweight and obese pregnant women (n = 100) in early pregnancy were analysed for IGFBP-1, phosphorylated IGFBP-1 (phIGFBP-1) and MMP-8. High-sensitivity CRP and GlycA were used as markers for low grade inflammation. GlycA and lipids were quantified using NMR. IGFBP-1 associated negatively with GlycA, evidenced by higher concentrations in the lowest quartile (median 1.53 (IQR 1.45–1.72)) compared to the highest (1.46 (1.39–1.55)) (P = 0.03). Several lipid metabolites, particularly HDL-cholesterol, correlated inversely with phIGFBP-1 (FDR<0.1). Nutritional status and diet contributed to the levels of IGFBP-1, demonstrated as an inverse correlation with maternal weight (Spearman r = -0.205, P = 0.04) and dietary intake of vitamin A (r = -0.253, P = 0.014) and a direct correlation with dietary intake of polyunsaturated fatty acids (Spearman r = 0.222, P = 0.03). MMP-8 correlated inversely with pyridoxine (r = -0.321, P = 0.002) and potassium (r = -0.220, P = 0.033). Maternal serum IGFBP-1 may contribute to maternal lipid metabolism in overweight and obese women during early pregnancy. These findings may be of importance in identification of metabolic disturbances preceding the adverse metabolic outcomes in pregnancy.
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spelling pubmed-74751812020-09-11 Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women Mokkala, Kati Juhila, Juuso Houttu, Noora Sorsa, Timo Laitinen, Kirsi Heliyon Research Article Lower level of insulin-like growth factor-binding protein (IGFBP-1) has been observed in insulin resistance, while higher level of matrix metalloproteinase-8 (MMP-8) has been linked to obesity. The aim here was to study in overweight and obese women, typically manifesting with insulin resistance, whether IGFBP-1 and MMP-8 are related to and reflect systemic low-grade inflammation, metabolism and diet. Fasting serum from overweight and obese pregnant women (n = 100) in early pregnancy were analysed for IGFBP-1, phosphorylated IGFBP-1 (phIGFBP-1) and MMP-8. High-sensitivity CRP and GlycA were used as markers for low grade inflammation. GlycA and lipids were quantified using NMR. IGFBP-1 associated negatively with GlycA, evidenced by higher concentrations in the lowest quartile (median 1.53 (IQR 1.45–1.72)) compared to the highest (1.46 (1.39–1.55)) (P = 0.03). Several lipid metabolites, particularly HDL-cholesterol, correlated inversely with phIGFBP-1 (FDR<0.1). Nutritional status and diet contributed to the levels of IGFBP-1, demonstrated as an inverse correlation with maternal weight (Spearman r = -0.205, P = 0.04) and dietary intake of vitamin A (r = -0.253, P = 0.014) and a direct correlation with dietary intake of polyunsaturated fatty acids (Spearman r = 0.222, P = 0.03). MMP-8 correlated inversely with pyridoxine (r = -0.321, P = 0.002) and potassium (r = -0.220, P = 0.033). Maternal serum IGFBP-1 may contribute to maternal lipid metabolism in overweight and obese women during early pregnancy. These findings may be of importance in identification of metabolic disturbances preceding the adverse metabolic outcomes in pregnancy. Elsevier 2020-08-30 /pmc/articles/PMC7475181/ /pubmed/32923723 http://dx.doi.org/10.1016/j.heliyon.2020.e04788 Text en © 2020 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Mokkala, Kati
Juhila, Juuso
Houttu, Noora
Sorsa, Timo
Laitinen, Kirsi
Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women
title Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women
title_full Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women
title_fullStr Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women
title_full_unstemmed Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women
title_short Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women
title_sort early pregnancy serum igfbp-1 relates to lipid profile in overweight and obese women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475181/
https://www.ncbi.nlm.nih.gov/pubmed/32923723
http://dx.doi.org/10.1016/j.heliyon.2020.e04788
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