Cargando…

Conversion ratio of tacrolimus switching from intravenous infusion to oral administration after lung transplantation

BACKGROUND: To investigate the conversion ratio of tacrolimus switching from intravenous infusion to oral administration in patients after lung transplantation. METHODS: We retrospectively recruited patients received lung transplantation in the First Affiliated Hospital of Guangzhou Medical Hospital...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Chun, Xi, Yin, Chen, Wen-Ying, Sang, Lin, Liu, Dong-Dong, Zhang, Rong, Chen, Si-Bei, Zhang, Jie, Pan, Jie-Yi, Xv, Yong-Hao, Nong, Lin-Bo, Li, Yi-Min, Liu, Xiao-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475590/
https://www.ncbi.nlm.nih.gov/pubmed/32944341
http://dx.doi.org/10.21037/jtd-20-1191
_version_ 1783579539806355456
author Yang, Chun
Xi, Yin
Chen, Wen-Ying
Sang, Lin
Liu, Dong-Dong
Zhang, Rong
Chen, Si-Bei
Zhang, Jie
Pan, Jie-Yi
Xv, Yong-Hao
Nong, Lin-Bo
Li, Yi-Min
Liu, Xiao-Qing
author_facet Yang, Chun
Xi, Yin
Chen, Wen-Ying
Sang, Lin
Liu, Dong-Dong
Zhang, Rong
Chen, Si-Bei
Zhang, Jie
Pan, Jie-Yi
Xv, Yong-Hao
Nong, Lin-Bo
Li, Yi-Min
Liu, Xiao-Qing
author_sort Yang, Chun
collection PubMed
description BACKGROUND: To investigate the conversion ratio of tacrolimus switching from intravenous infusion to oral administration in patients after lung transplantation. METHODS: We retrospectively recruited patients received lung transplantation in the First Affiliated Hospital of Guangzhou Medical Hospital from January 2015 to June 2019. The blood concentration of tacrolimus administrated through intravenous infusion and oral administration were collected. The blood concentration, concentration/dose ratio (C/D), and (C/Dpo)/(C/Div) ratio were analyzed to explore the conversion ratio of tacrolimus switching from intravenous infusion to oral administration, as combined medication of tacrolimus and caspofungin were used. RESULTS: The concentration of intravenously administered tacrolimus was significantly higher than that of oral administration; the C/D ratio of intravenously administrated tacrolimus (C/Div) was significantly higher than that of the oral administration (C/Dpo). There was a significant correlation between C/Dpo and C/Div (R(2) =0.774, P<0.001). The conversion ratio of tacrolimus from intravenous administration to oral administration was 1:7.4, as combined medication of tacrolimus and caspofungin were used. CONCLUSIONS: The conversion ratio of tacrolimus switching from intravenous to oral administration is 1:7.4 in the combination treatment of tacrolimus and caspofungin after lung transplantation.
format Online
Article
Text
id pubmed-7475590
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-74755902020-09-16 Conversion ratio of tacrolimus switching from intravenous infusion to oral administration after lung transplantation Yang, Chun Xi, Yin Chen, Wen-Ying Sang, Lin Liu, Dong-Dong Zhang, Rong Chen, Si-Bei Zhang, Jie Pan, Jie-Yi Xv, Yong-Hao Nong, Lin-Bo Li, Yi-Min Liu, Xiao-Qing J Thorac Dis Original Article BACKGROUND: To investigate the conversion ratio of tacrolimus switching from intravenous infusion to oral administration in patients after lung transplantation. METHODS: We retrospectively recruited patients received lung transplantation in the First Affiliated Hospital of Guangzhou Medical Hospital from January 2015 to June 2019. The blood concentration of tacrolimus administrated through intravenous infusion and oral administration were collected. The blood concentration, concentration/dose ratio (C/D), and (C/Dpo)/(C/Div) ratio were analyzed to explore the conversion ratio of tacrolimus switching from intravenous infusion to oral administration, as combined medication of tacrolimus and caspofungin were used. RESULTS: The concentration of intravenously administered tacrolimus was significantly higher than that of oral administration; the C/D ratio of intravenously administrated tacrolimus (C/Div) was significantly higher than that of the oral administration (C/Dpo). There was a significant correlation between C/Dpo and C/Div (R(2) =0.774, P<0.001). The conversion ratio of tacrolimus from intravenous administration to oral administration was 1:7.4, as combined medication of tacrolimus and caspofungin were used. CONCLUSIONS: The conversion ratio of tacrolimus switching from intravenous to oral administration is 1:7.4 in the combination treatment of tacrolimus and caspofungin after lung transplantation. AME Publishing Company 2020-08 /pmc/articles/PMC7475590/ /pubmed/32944341 http://dx.doi.org/10.21037/jtd-20-1191 Text en 2020 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Yang, Chun
Xi, Yin
Chen, Wen-Ying
Sang, Lin
Liu, Dong-Dong
Zhang, Rong
Chen, Si-Bei
Zhang, Jie
Pan, Jie-Yi
Xv, Yong-Hao
Nong, Lin-Bo
Li, Yi-Min
Liu, Xiao-Qing
Conversion ratio of tacrolimus switching from intravenous infusion to oral administration after lung transplantation
title Conversion ratio of tacrolimus switching from intravenous infusion to oral administration after lung transplantation
title_full Conversion ratio of tacrolimus switching from intravenous infusion to oral administration after lung transplantation
title_fullStr Conversion ratio of tacrolimus switching from intravenous infusion to oral administration after lung transplantation
title_full_unstemmed Conversion ratio of tacrolimus switching from intravenous infusion to oral administration after lung transplantation
title_short Conversion ratio of tacrolimus switching from intravenous infusion to oral administration after lung transplantation
title_sort conversion ratio of tacrolimus switching from intravenous infusion to oral administration after lung transplantation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475590/
https://www.ncbi.nlm.nih.gov/pubmed/32944341
http://dx.doi.org/10.21037/jtd-20-1191
work_keys_str_mv AT yangchun conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT xiyin conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT chenwenying conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT sanglin conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT liudongdong conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT zhangrong conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT chensibei conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT zhangjie conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT panjieyi conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT xvyonghao conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT nonglinbo conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT liyimin conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation
AT liuxiaoqing conversionratiooftacrolimusswitchingfromintravenousinfusiontooraladministrationafterlungtransplantation