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Treatment of Hypertensive Heart Disease by Targeting Smad3 Signaling in Mice

Transforming growth factor β (TGF-β)/Smad3 signaling plays a central role in chronic heart disease. Here, we report that targeting Smad3 with a Smad3 inhibitor SIS3 in an established mouse model of hypertension significantly improved cardiac dysfunctions by preserving the left ventricle (LV) ejectio...

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Detalles Bibliográficos
Autores principales:	Meng, Jinxiu, Qin, Yuyan, Chen, Junzhe, Wei, Lihua, Huang, Xiao-ru, Yu, Xiyong, Lan, Hui-yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475647/ https://www.ncbi.nlm.nih.gov/pubmed/32953930 http://dx.doi.org/10.1016/j.omtm.2020.08.003

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