Mechanisms of sex hormones in autoimmunity: focus on EAE

Sex-related differences in the occurrence of autoimmune diseases is well documented, with females showing a greater propensity to develop these diseases than their male counterparts. Sex hormones, namely dihydrotestosterone and estrogens, have been shown to ameliorate the severity of inflammatory di...

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Autores principales: Lasrado, Ninaad, Jia, Ting, Massilamany, Chandirasegaran, Franco, Rodrigo, Illes, Zsolt, Reddy, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475723/
https://www.ncbi.nlm.nih.gov/pubmed/32894183
http://dx.doi.org/10.1186/s13293-020-00325-4
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author Lasrado, Ninaad
Jia, Ting
Massilamany, Chandirasegaran
Franco, Rodrigo
Illes, Zsolt
Reddy, Jay
author_facet Lasrado, Ninaad
Jia, Ting
Massilamany, Chandirasegaran
Franco, Rodrigo
Illes, Zsolt
Reddy, Jay
author_sort Lasrado, Ninaad
collection PubMed
description Sex-related differences in the occurrence of autoimmune diseases is well documented, with females showing a greater propensity to develop these diseases than their male counterparts. Sex hormones, namely dihydrotestosterone and estrogens, have been shown to ameliorate the severity of inflammatory diseases. Immunologically, the beneficial effects of sex hormones have been ascribed to the suppression of effector lymphocyte responses accompanied by immune deviation from pro-inflammatory to anti-inflammatory cytokine production. In this review, we present our view of the mechanisms of sex hormones that contribute to their ability to suppress autoimmune responses with an emphasis on the pathogenesis of experimental autoimmune encephalomyelitis.
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spelling pubmed-74757232020-09-08 Mechanisms of sex hormones in autoimmunity: focus on EAE Lasrado, Ninaad Jia, Ting Massilamany, Chandirasegaran Franco, Rodrigo Illes, Zsolt Reddy, Jay Biol Sex Differ Review Sex-related differences in the occurrence of autoimmune diseases is well documented, with females showing a greater propensity to develop these diseases than their male counterparts. Sex hormones, namely dihydrotestosterone and estrogens, have been shown to ameliorate the severity of inflammatory diseases. Immunologically, the beneficial effects of sex hormones have been ascribed to the suppression of effector lymphocyte responses accompanied by immune deviation from pro-inflammatory to anti-inflammatory cytokine production. In this review, we present our view of the mechanisms of sex hormones that contribute to their ability to suppress autoimmune responses with an emphasis on the pathogenesis of experimental autoimmune encephalomyelitis. BioMed Central 2020-09-07 /pmc/articles/PMC7475723/ /pubmed/32894183 http://dx.doi.org/10.1186/s13293-020-00325-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lasrado, Ninaad
Jia, Ting
Massilamany, Chandirasegaran
Franco, Rodrigo
Illes, Zsolt
Reddy, Jay
Mechanisms of sex hormones in autoimmunity: focus on EAE
title Mechanisms of sex hormones in autoimmunity: focus on EAE
title_full Mechanisms of sex hormones in autoimmunity: focus on EAE
title_fullStr Mechanisms of sex hormones in autoimmunity: focus on EAE
title_full_unstemmed Mechanisms of sex hormones in autoimmunity: focus on EAE
title_short Mechanisms of sex hormones in autoimmunity: focus on EAE
title_sort mechanisms of sex hormones in autoimmunity: focus on eae
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475723/
https://www.ncbi.nlm.nih.gov/pubmed/32894183
http://dx.doi.org/10.1186/s13293-020-00325-4
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