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Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study

Background: Various surface treatments have been tested for titanium implants aiming at increasing their surface biocompatibility and their biological characteristics, but also the efficiency of the implant surface will have to be improved to drastically decrease peri-implantite and mucosite. In fac...

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Autores principales: Scarano, Antonio, Carinci, Francesco, Orsini, Tiziana, Valbonetti, Luca, Qorri, Erda, Bignozzi, Carlo Alberto, Lorusso, Felice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475867/
https://www.ncbi.nlm.nih.gov/pubmed/32824141
http://dx.doi.org/10.3390/ma13163613
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author Scarano, Antonio
Carinci, Francesco
Orsini, Tiziana
Valbonetti, Luca
Qorri, Erda
Bignozzi, Carlo Alberto
Lorusso, Felice
author_facet Scarano, Antonio
Carinci, Francesco
Orsini, Tiziana
Valbonetti, Luca
Qorri, Erda
Bignozzi, Carlo Alberto
Lorusso, Felice
author_sort Scarano, Antonio
collection PubMed
description Background: Various surface treatments have been tested for titanium implants aiming at increasing their surface biocompatibility and their biological characteristics, but also the efficiency of the implant surface will have to be improved to drastically decrease peri-implantite and mucosite. In fact, the peri-implantitis and peri-implant mucositis have a high incidence in clinical practice. The nanofabrication techniques that offer the possibility to achieve the implant surface that reduces bacterial colonization could influence the osteointegration. The aim of this research was to evaluate the bone response to titanium implants coated with a bifunctional molecule with antimicrobic activity consisting of a combination of silver ions covalently bound to titanium dioxide nanoparticles. Methods: A total of 36 implants were inserted into 18 older New Zealand white male rabbits. They had two different surfaces. The implants Control group was characterized by an acid-etched and sandblasted surface treatment, and the Test implants had an acid-etched and sandblasted surface coated with a silver ion covalently bound to titanium dioxide nanoparticles in the solution. Results: No statistically significant difference of the bone density was evidenced between Control and Test implants at two weeks (p-value = 0.623), four weeks (p-value = 0.339), and eight weeks (p-value = 0.461). Moreover, no statistically significant difference of the bone-implant contact percentage was evidenced between Control and Test implants at two weeks (p-value = 0.938), four weeks (p-value = 0.307), and eight weeks (p-value = 0.294). The effectiveness of the present investigation demonstrated no adverse effects on osseointegration, and no statistically significant differences were observed in the bone density and percentage of bone-implant contact between Test and Control implants at all the experimental time points (two, four, and eight weeks). Conclusions: Titanium implants coated with the silver-anatase solution bind very well to the bone and did not have an adverse effect on the bone tissue in a rabbit model. These facts suggest possible clinical applications for the silver composition.
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spelling pubmed-74758672020-09-17 Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study Scarano, Antonio Carinci, Francesco Orsini, Tiziana Valbonetti, Luca Qorri, Erda Bignozzi, Carlo Alberto Lorusso, Felice Materials (Basel) Article Background: Various surface treatments have been tested for titanium implants aiming at increasing their surface biocompatibility and their biological characteristics, but also the efficiency of the implant surface will have to be improved to drastically decrease peri-implantite and mucosite. In fact, the peri-implantitis and peri-implant mucositis have a high incidence in clinical practice. The nanofabrication techniques that offer the possibility to achieve the implant surface that reduces bacterial colonization could influence the osteointegration. The aim of this research was to evaluate the bone response to titanium implants coated with a bifunctional molecule with antimicrobic activity consisting of a combination of silver ions covalently bound to titanium dioxide nanoparticles. Methods: A total of 36 implants were inserted into 18 older New Zealand white male rabbits. They had two different surfaces. The implants Control group was characterized by an acid-etched and sandblasted surface treatment, and the Test implants had an acid-etched and sandblasted surface coated with a silver ion covalently bound to titanium dioxide nanoparticles in the solution. Results: No statistically significant difference of the bone density was evidenced between Control and Test implants at two weeks (p-value = 0.623), four weeks (p-value = 0.339), and eight weeks (p-value = 0.461). Moreover, no statistically significant difference of the bone-implant contact percentage was evidenced between Control and Test implants at two weeks (p-value = 0.938), four weeks (p-value = 0.307), and eight weeks (p-value = 0.294). The effectiveness of the present investigation demonstrated no adverse effects on osseointegration, and no statistically significant differences were observed in the bone density and percentage of bone-implant contact between Test and Control implants at all the experimental time points (two, four, and eight weeks). Conclusions: Titanium implants coated with the silver-anatase solution bind very well to the bone and did not have an adverse effect on the bone tissue in a rabbit model. These facts suggest possible clinical applications for the silver composition. MDPI 2020-08-15 /pmc/articles/PMC7475867/ /pubmed/32824141 http://dx.doi.org/10.3390/ma13163613 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scarano, Antonio
Carinci, Francesco
Orsini, Tiziana
Valbonetti, Luca
Qorri, Erda
Bignozzi, Carlo Alberto
Lorusso, Felice
Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study
title Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study
title_full Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study
title_fullStr Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study
title_full_unstemmed Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study
title_short Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study
title_sort titanium implants coated with a bifunctional molecule with antimicrobic activity: a rabbit study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475867/
https://www.ncbi.nlm.nih.gov/pubmed/32824141
http://dx.doi.org/10.3390/ma13163613
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