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Telomere-related Markers for Cancer
Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and essential to chromosome stability/integrity. In normal human cells, telomere length erodes progressively with each round of cell divisions, which serves as an important barrier to uncontrolled proliferation and m...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475940/ https://www.ncbi.nlm.nih.gov/pubmed/31903880 http://dx.doi.org/10.2174/1568026620666200106145340 |
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author | Yuan, Xiaotian Dai, Mingkai Xu, Dawei |
author_facet | Yuan, Xiaotian Dai, Mingkai Xu, Dawei |
author_sort | Yuan, Xiaotian |
collection | PubMed |
description | Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and essential to chromosome stability/integrity. In normal human cells, telomere length erodes progressively with each round of cell divisions, which serves as an important barrier to uncontrolled proliferation and malignant transformation. In sharp contrast, telomere maintenance is a key feature of human malignant cells and required for their infinite proliferation and maintenance of other cancer hallmarks as well. Thus, a telomere-based anti-cancer strategy has long been suggested. However, clinically efficient and specific drugs targeting cancer telomere-maintenance have still been in their infancy thus far. To achieve this goal, it is highly necessary to elucidate how exactly cancer cells maintain functional telomeres. In the last two decades, numerous studies have provided profound mechanistic insights, and the identified mechanisms include the aberrant activation of telomerase or the alternative lengthening of telomere pathway responsible for telomere elongation, dysregulation and mutation of telomere-associated factors, and other telomere homeostasis-related signaling nodes. In the present review, these various strategies employed by malignant cells to regulate their telomere length, structure and function have been summarized, and potential implications of these findings in the rational development of telomere-based cancer therapy and other clinical applications for precision oncology have been discussed. |
format | Online Article Text |
id | pubmed-7475940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-74759402020-09-16 Telomere-related Markers for Cancer Yuan, Xiaotian Dai, Mingkai Xu, Dawei Curr Top Med Chem Chemistry Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and essential to chromosome stability/integrity. In normal human cells, telomere length erodes progressively with each round of cell divisions, which serves as an important barrier to uncontrolled proliferation and malignant transformation. In sharp contrast, telomere maintenance is a key feature of human malignant cells and required for their infinite proliferation and maintenance of other cancer hallmarks as well. Thus, a telomere-based anti-cancer strategy has long been suggested. However, clinically efficient and specific drugs targeting cancer telomere-maintenance have still been in their infancy thus far. To achieve this goal, it is highly necessary to elucidate how exactly cancer cells maintain functional telomeres. In the last two decades, numerous studies have provided profound mechanistic insights, and the identified mechanisms include the aberrant activation of telomerase or the alternative lengthening of telomere pathway responsible for telomere elongation, dysregulation and mutation of telomere-associated factors, and other telomere homeostasis-related signaling nodes. In the present review, these various strategies employed by malignant cells to regulate their telomere length, structure and function have been summarized, and potential implications of these findings in the rational development of telomere-based cancer therapy and other clinical applications for precision oncology have been discussed. Bentham Science Publishers 2020-03 2020-03 /pmc/articles/PMC7475940/ /pubmed/31903880 http://dx.doi.org/10.2174/1568026620666200106145340 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Chemistry Yuan, Xiaotian Dai, Mingkai Xu, Dawei Telomere-related Markers for Cancer |
title | Telomere-related Markers for Cancer |
title_full | Telomere-related Markers for Cancer |
title_fullStr | Telomere-related Markers for Cancer |
title_full_unstemmed | Telomere-related Markers for Cancer |
title_short | Telomere-related Markers for Cancer |
title_sort | telomere-related markers for cancer |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475940/ https://www.ncbi.nlm.nih.gov/pubmed/31903880 http://dx.doi.org/10.2174/1568026620666200106145340 |
work_keys_str_mv | AT yuanxiaotian telomererelatedmarkersforcancer AT daimingkai telomererelatedmarkersforcancer AT xudawei telomererelatedmarkersforcancer |