Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TR...

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Autores principales: Marks, Michelle, Steele, Chad, Moore, Wendy C, Meyers, Deborah A, Rector, Brian, Ampleford, Elizabeth, Bleecker, Eugene R, Hastie, Annette T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476262/
https://www.ncbi.nlm.nih.gov/pubmed/32482836
http://dx.doi.org/10.1136/thoraxjnl-2019-214496
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author Marks, Michelle
Steele, Chad
Moore, Wendy C
Meyers, Deborah A
Rector, Brian
Ampleford, Elizabeth
Bleecker, Eugene R
Hastie, Annette T
author_facet Marks, Michelle
Steele, Chad
Moore, Wendy C
Meyers, Deborah A
Rector, Brian
Ampleford, Elizabeth
Bleecker, Eugene R
Hastie, Annette T
author_sort Marks, Michelle
collection PubMed
description Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation.
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spelling pubmed-74762622020-09-30 Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study Marks, Michelle Steele, Chad Moore, Wendy C Meyers, Deborah A Rector, Brian Ampleford, Elizabeth Bleecker, Eugene R Hastie, Annette T Thorax Brief Communication Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation. BMJ Publishing Group 2020-09 2020-06-01 /pmc/articles/PMC7476262/ /pubmed/32482836 http://dx.doi.org/10.1136/thoraxjnl-2019-214496 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Marks, Michelle
Steele, Chad
Moore, Wendy C
Meyers, Deborah A
Rector, Brian
Ampleford, Elizabeth
Bleecker, Eugene R
Hastie, Annette T
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study
title Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study
title_full Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study
title_fullStr Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study
title_full_unstemmed Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study
title_short Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study
title_sort tumour necrosis factor-related apoptosis-inducing ligand (trail) and receptors in type 1, type 2 and type 17 inflammation in cross-sectional asthma study
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476262/
https://www.ncbi.nlm.nih.gov/pubmed/32482836
http://dx.doi.org/10.1136/thoraxjnl-2019-214496
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