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Association of social relationships with incident cardiovascular events and all-cause mortality

OBJECTIVE: To examine how different aspects of social relationships are associated with incident cardiovascular events and all-cause mortality. METHODS: In 4139 participants from the population-based Heinz Nixdorf Recall study without previous cardiovascular disease (mean (SD) age 59.1 (7.7) years,...

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Autores principales: Gronewold, Janine, Kropp, Rene, Lehmann, Nils, Schmidt, Börge, Weyers, Simone, Siegrist, Johanne, Dragano, Nico, Jöckel, Karl-Heinz, Erbel, Raimund, Hermann, Dirk M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476279/
https://www.ncbi.nlm.nih.gov/pubmed/32165451
http://dx.doi.org/10.1136/heartjnl-2019-316250
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author Gronewold, Janine
Kropp, Rene
Lehmann, Nils
Schmidt, Börge
Weyers, Simone
Siegrist, Johanne
Dragano, Nico
Jöckel, Karl-Heinz
Erbel, Raimund
Hermann, Dirk M
author_facet Gronewold, Janine
Kropp, Rene
Lehmann, Nils
Schmidt, Börge
Weyers, Simone
Siegrist, Johanne
Dragano, Nico
Jöckel, Karl-Heinz
Erbel, Raimund
Hermann, Dirk M
author_sort Gronewold, Janine
collection PubMed
description OBJECTIVE: To examine how different aspects of social relationships are associated with incident cardiovascular events and all-cause mortality. METHODS: In 4139 participants from the population-based Heinz Nixdorf Recall study without previous cardiovascular disease (mean (SD) age 59.1 (7.7) years, 46.7% men), the association of self-reported instrumental, emotional and financial support and social integration at baseline with incident fatal and non-fatal cardiovascular events and all-cause mortality during 13.4-year follow-up was assessed in five different multivariable Cox proportional hazards regression models: minimally adjusted model (adjusting for age, sex, social integration or social support, respectively); biological model (minimally adjusted+systolic blood pressure, low-density and high-density lipoprotein cholesterol, glycated haemoglobin, body mass index, antihypertensive medication, lipid-lowering medication and antidiabetic medication); health behaviour model (minimally adjusted+alcohol consumption, smoking and physical activity); socioeconomic model (minimally adjusted+income, education and employment); and depression model (minimally adjusted+depression, antidepressants and anxiolytics). RESULTS: 339 cardiovascular events and 530 deaths occurred during follow-up. Lack of financial support was associated with an increased cardiovascular event risk (minimally adjusted HR=1.30(95% CI 1.01 to 1.67)). Lack of social integration (social isolation) was associated with increased mortality (minimally adjusted HR=1.47 (95% CI 1.09 to 1.97)). Effect estimates did not decrease to a relevant extent in any regression model. CONCLUSIONS: Perceiving a lack of financial support is associated with a higher cardiovascular event incidence, and being socially isolated is associated with increased all-cause mortality. Future studies should investigate how persons with deficient social relationships could benefit from targeted interventions.
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spelling pubmed-74762792020-09-30 Association of social relationships with incident cardiovascular events and all-cause mortality Gronewold, Janine Kropp, Rene Lehmann, Nils Schmidt, Börge Weyers, Simone Siegrist, Johanne Dragano, Nico Jöckel, Karl-Heinz Erbel, Raimund Hermann, Dirk M Heart Cardiac Risk Factors and Prevention OBJECTIVE: To examine how different aspects of social relationships are associated with incident cardiovascular events and all-cause mortality. METHODS: In 4139 participants from the population-based Heinz Nixdorf Recall study without previous cardiovascular disease (mean (SD) age 59.1 (7.7) years, 46.7% men), the association of self-reported instrumental, emotional and financial support and social integration at baseline with incident fatal and non-fatal cardiovascular events and all-cause mortality during 13.4-year follow-up was assessed in five different multivariable Cox proportional hazards regression models: minimally adjusted model (adjusting for age, sex, social integration or social support, respectively); biological model (minimally adjusted+systolic blood pressure, low-density and high-density lipoprotein cholesterol, glycated haemoglobin, body mass index, antihypertensive medication, lipid-lowering medication and antidiabetic medication); health behaviour model (minimally adjusted+alcohol consumption, smoking and physical activity); socioeconomic model (minimally adjusted+income, education and employment); and depression model (minimally adjusted+depression, antidepressants and anxiolytics). RESULTS: 339 cardiovascular events and 530 deaths occurred during follow-up. Lack of financial support was associated with an increased cardiovascular event risk (minimally adjusted HR=1.30(95% CI 1.01 to 1.67)). Lack of social integration (social isolation) was associated with increased mortality (minimally adjusted HR=1.47 (95% CI 1.09 to 1.97)). Effect estimates did not decrease to a relevant extent in any regression model. CONCLUSIONS: Perceiving a lack of financial support is associated with a higher cardiovascular event incidence, and being socially isolated is associated with increased all-cause mortality. Future studies should investigate how persons with deficient social relationships could benefit from targeted interventions. BMJ Publishing Group 2020-09 2020-03-12 /pmc/articles/PMC7476279/ /pubmed/32165451 http://dx.doi.org/10.1136/heartjnl-2019-316250 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Cardiac Risk Factors and Prevention
Gronewold, Janine
Kropp, Rene
Lehmann, Nils
Schmidt, Börge
Weyers, Simone
Siegrist, Johanne
Dragano, Nico
Jöckel, Karl-Heinz
Erbel, Raimund
Hermann, Dirk M
Association of social relationships with incident cardiovascular events and all-cause mortality
title Association of social relationships with incident cardiovascular events and all-cause mortality
title_full Association of social relationships with incident cardiovascular events and all-cause mortality
title_fullStr Association of social relationships with incident cardiovascular events and all-cause mortality
title_full_unstemmed Association of social relationships with incident cardiovascular events and all-cause mortality
title_short Association of social relationships with incident cardiovascular events and all-cause mortality
title_sort association of social relationships with incident cardiovascular events and all-cause mortality
topic Cardiac Risk Factors and Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476279/
https://www.ncbi.nlm.nih.gov/pubmed/32165451
http://dx.doi.org/10.1136/heartjnl-2019-316250
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