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Applications of PET in Diagnosis and Prognosis of Leukemia
As a malignant hematopoietic stem cell disease, leukemia remains life-threatening due to its increasing incidence rate and mortality rate. Therefore, its early diagnosis and treatment play a very important role. In the present work, we systematically reviewed the current applications and future dire...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476341/ https://www.ncbi.nlm.nih.gov/pubmed/32875963 http://dx.doi.org/10.1177/1533033820956993 |
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author | Zhao, Zixuan Hu, Yanwen Li, Jihui Zhou, Yeye Zhang, Bin Deng, Shengming |
author_facet | Zhao, Zixuan Hu, Yanwen Li, Jihui Zhou, Yeye Zhang, Bin Deng, Shengming |
author_sort | Zhao, Zixuan |
collection | PubMed |
description | As a malignant hematopoietic stem cell disease, leukemia remains life-threatening due to its increasing incidence rate and mortality rate. Therefore, its early diagnosis and treatment play a very important role. In the present work, we systematically reviewed the current applications and future directions of positron emission tomography (PET) in patients with leukemia, especially (18)F-FDG PET/CT. As a useful imaging approach, PET significantly contributes to the diagnosis and treatment of different types of leukemia, especially in the evaluation of extramedullary infiltration, monitoring of leukemia relapse, detection of Richter’s transformation (RT), and assessment of the inflammatory activity associated with acute graft versus host disease. Future investigations should be focused on the potential of PET/CT in the prediction of clinical outcomes in patients with leukemia and the utility of novel radiotracers. |
format | Online Article Text |
id | pubmed-7476341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-74763412020-09-17 Applications of PET in Diagnosis and Prognosis of Leukemia Zhao, Zixuan Hu, Yanwen Li, Jihui Zhou, Yeye Zhang, Bin Deng, Shengming Technol Cancer Res Treat Review As a malignant hematopoietic stem cell disease, leukemia remains life-threatening due to its increasing incidence rate and mortality rate. Therefore, its early diagnosis and treatment play a very important role. In the present work, we systematically reviewed the current applications and future directions of positron emission tomography (PET) in patients with leukemia, especially (18)F-FDG PET/CT. As a useful imaging approach, PET significantly contributes to the diagnosis and treatment of different types of leukemia, especially in the evaluation of extramedullary infiltration, monitoring of leukemia relapse, detection of Richter’s transformation (RT), and assessment of the inflammatory activity associated with acute graft versus host disease. Future investigations should be focused on the potential of PET/CT in the prediction of clinical outcomes in patients with leukemia and the utility of novel radiotracers. SAGE Publications 2020-09-02 /pmc/articles/PMC7476341/ /pubmed/32875963 http://dx.doi.org/10.1177/1533033820956993 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Zhao, Zixuan Hu, Yanwen Li, Jihui Zhou, Yeye Zhang, Bin Deng, Shengming Applications of PET in Diagnosis and Prognosis of Leukemia |
title | Applications of PET in Diagnosis and Prognosis of Leukemia |
title_full | Applications of PET in Diagnosis and Prognosis of Leukemia |
title_fullStr | Applications of PET in Diagnosis and Prognosis of Leukemia |
title_full_unstemmed | Applications of PET in Diagnosis and Prognosis of Leukemia |
title_short | Applications of PET in Diagnosis and Prognosis of Leukemia |
title_sort | applications of pet in diagnosis and prognosis of leukemia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476341/ https://www.ncbi.nlm.nih.gov/pubmed/32875963 http://dx.doi.org/10.1177/1533033820956993 |
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