Cargando…

Potential treatment with Chinese and Western medicine targeting NSP14 of SARS-CoV-2

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious global health threat. This raises an urgent need for the development of effective drugs against the deadly disease. SARS-CoV-2 non-structural protein 14 (NSP14) car...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Chao, Zhu, Xiaoxiao, Lu, Yiyao, Zhang, Xianqin, Jia, Xu, Yang, Tai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Xi'an Jiaotong University 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476502/ https://www.ncbi.nlm.nih.gov/pubmed/32923004 http://dx.doi.org/10.1016/j.jpha.2020.08.002

Ejemplares similares

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
por: Yuen, Chun-Kit, et al.
Publicado: (2020)

A Computational Study on the Interaction of NSP10 and NSP14: Unraveling the RNA Synthesis Proofreading Mechanism in SARS-CoV-2, SARS-CoV, and MERS-CoV
por: Sarma, Himakshi, et al.
Publicado: (2022)

Activation of the SARS-CoV-2 NSP14 3′–5′ exoribonuclease by NSP10 and response to antiviral inhibitors
por: Riccio, Amanda A., et al.
Publicado: (2021)

Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening
por: Bobrovs, Raitis, et al.
Publicado: (2021)

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2
por: Ogando, Natacha S., et al.
Publicado: (2020)

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
por: Kirchdoerfer, Robert N., et al.
Publicado: (2019)

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16
por: Kozielski, Frank, et al.
Publicado: (2021)

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease
por: Canal, Berta, et al.
Publicado: (2021)

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity
por: Czarna, Anna, et al.
Publicado: (2022)

Exploring the therapeutic nature of limonoids and triterpenoids against SARS-CoV-2 by targeting nsp13, nsp14, and nsp15 through molecular docking and dynamics simulations
por: Vardhan, Seshu, et al.
Publicado: (2021)

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
por: Shannon, Ashleigh, et al.
Publicado: (2020)

Genomic diversity of SARS-CoV-2 can be accelerated by mutations in the nsp14 gene
por: Takada, Kosuke, et al.
Publicado: (2023)

Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors
por: Štefek, Milan, et al.
Publicado: (2023)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
por: Benoni, Roberto, et al.
Publicado: (2021)

Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2
por: Azizogli, Abdul-Rahman, et al.
Publicado: (2023)

SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling
por: Li, Tai-Wei, et al.
Publicado: (2022)

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein
por: Hsu, Jack Chun-Chieh, et al.
Publicado: (2021)

SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome
por: Zaffagni, Michela, et al.
Publicado: (2022)

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein
por: Walter, Marius, et al.
Publicado: (2022)

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein
por: Walter, Marius, et al.
Publicado: (2022)

Substrate Specificity and Kinetics of RNA Hydrolysis by SARS-CoV-2 NSP10/14 Exonuclease
por: Dangerfield, Tyler L., et al.
Publicado: (2022)

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors
por: Bobileva, Olga, et al.
Publicado: (2023)

NMR assignment of the SARS-CoV protein nsp1
por: Almeida, M. S., et al.
Publicado: (2006)

In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors
por: Gurung, Arun Bahadur
Publicado: (2020)

Identification of novel mutations in the methyltransferase complex (Nsp10-Nsp16) of SARS-CoV-2
por: Azad, Gajendra Kumar
Publicado: (2020)

Insights into SARS-CoV transcription and replication from the structure of the nsp7–nsp8 hexadecamer
por: Zhai, Yujia, et al.
Publicado: (2005)

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing
por: Eckerle, Lance D., et al.
Publicado: (2010)

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2
por: Peng, Qi, et al.
Publicado: (2020)

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity
por: Lin, Sheng, et al.
Publicado: (2021)

SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1
por: Zhang, Shilei, et al.
Publicado: (2022)

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine
por: Rosas-Lemus, Monica, et al.
Publicado: (2020)

Molecular cloning, expression, and purification of SARS-CoV nsp13
por: Fan, Zheng, et al.
Publicado: (2005)

Parsing the role of NSP1 in SARS-CoV-2 infection
por: Fisher, Tal, et al.
Publicado: (2022)

Parsing the role of NSP1 in SARS-CoV-2 infection
por: Fisher, Tal, et al.
Publicado: (2022)

Multi-targeting approach for nsp3, nsp9, nsp12 and nsp15 proteins of SARS-CoV-2 by Diosmin as illustrated by molecular docking and molecular dynamics simulation methodologies
por: Kumar, Sumit, et al.
Publicado: (2021)

Mutations of SARS-CoV-2 nsp14 exhibit strong association with increased genome-wide mutation load
por: Eskier, Doğa, et al.
Publicado: (2020)

Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry
por: Scholle, Michael D., et al.
Publicado: (2021)

SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation
por: Li, Taiwei, et al.
Publicado: (2021)

Exploring the pharmacological aspects of natural phytochemicals against SARS-CoV-2 Nsp14 through an in silico approach
por: De, Arkajit, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_b4o4kbqacle46h8rvti168353d