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Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications

The development of novel magnetic nanoparticles (MNPs) with satisfactory biocompatibility for biomedical applications has been the subject of extensive exploration over the past two decades. In this work, we synthesized superparamagnetic iron oxide MNPs coated with polystyrene sulfonic acid (PSS-MNP...

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Autores principales: Chen, Bo-Wei, He, Yun-Chi, Sung, Shian-Ying, Le, Trang Thi Huynh, Hsieh, Chia-Ling, Chen, Jiann-Yeu, Wei, Zung-Hang, Yao, Da-Jeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476547/
https://www.ncbi.nlm.nih.gov/pubmed/32939172
http://dx.doi.org/10.1080/14686996.2020.1790032
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author Chen, Bo-Wei
He, Yun-Chi
Sung, Shian-Ying
Le, Trang Thi Huynh
Hsieh, Chia-Ling
Chen, Jiann-Yeu
Wei, Zung-Hang
Yao, Da-Jeng
author_facet Chen, Bo-Wei
He, Yun-Chi
Sung, Shian-Ying
Le, Trang Thi Huynh
Hsieh, Chia-Ling
Chen, Jiann-Yeu
Wei, Zung-Hang
Yao, Da-Jeng
author_sort Chen, Bo-Wei
collection PubMed
description The development of novel magnetic nanoparticles (MNPs) with satisfactory biocompatibility for biomedical applications has been the subject of extensive exploration over the past two decades. In this work, we synthesized superparamagnetic iron oxide MNPs coated with polystyrene sulfonic acid (PSS-MNPs) and with a conventional co-precipitation method. The core size and hydrodynamic diameter of the PSS-MNPs were determined as 8–18 nm and 50–200 nm with a transmission electron microscopy and dynamic light scattering, respectively. The saturation magnetization of the particles was measured as 60 emu g(−1) with a superconducting quantum-interference-device magnetometer. The PSS content in the PSS-MNPs was 17% of the entire PSS-MNPs according to thermogravimetric analysis. Fourier-transform infrared spectra were recorded to detect the presence of SO(3)(−) groups, which confirmed a successful PSS coating. The structural properties of the PSS-MNPs, including the crystalline lattice, composition and phases, were characterized with an X-ray powder diffractometer and 3D nanometer-scale Raman microspectrometer. MTT assay and Prussian-blue staining showed that, although PSS-MNPs caused no cytotoxicity in both NIH-3T3 mouse fibroblasts and SK-HEP1 human liver-cancer cells up to 1000 μg mL(−1), SK-HEP1 cells exhibited significantly greater uptake of PSS-MNPs than NIH-3T3 cells. The low cytotoxicity and high biocompatibility of PSS-MNPs in human cancer cells demonstrated in the present work might have prospective applications for drug delivery.
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spelling pubmed-74765472020-09-15 Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications Chen, Bo-Wei He, Yun-Chi Sung, Shian-Ying Le, Trang Thi Huynh Hsieh, Chia-Ling Chen, Jiann-Yeu Wei, Zung-Hang Yao, Da-Jeng Sci Technol Adv Mater Bio-Inspired and Biomedical Materials The development of novel magnetic nanoparticles (MNPs) with satisfactory biocompatibility for biomedical applications has been the subject of extensive exploration over the past two decades. In this work, we synthesized superparamagnetic iron oxide MNPs coated with polystyrene sulfonic acid (PSS-MNPs) and with a conventional co-precipitation method. The core size and hydrodynamic diameter of the PSS-MNPs were determined as 8–18 nm and 50–200 nm with a transmission electron microscopy and dynamic light scattering, respectively. The saturation magnetization of the particles was measured as 60 emu g(−1) with a superconducting quantum-interference-device magnetometer. The PSS content in the PSS-MNPs was 17% of the entire PSS-MNPs according to thermogravimetric analysis. Fourier-transform infrared spectra were recorded to detect the presence of SO(3)(−) groups, which confirmed a successful PSS coating. The structural properties of the PSS-MNPs, including the crystalline lattice, composition and phases, were characterized with an X-ray powder diffractometer and 3D nanometer-scale Raman microspectrometer. MTT assay and Prussian-blue staining showed that, although PSS-MNPs caused no cytotoxicity in both NIH-3T3 mouse fibroblasts and SK-HEP1 human liver-cancer cells up to 1000 μg mL(−1), SK-HEP1 cells exhibited significantly greater uptake of PSS-MNPs than NIH-3T3 cells. The low cytotoxicity and high biocompatibility of PSS-MNPs in human cancer cells demonstrated in the present work might have prospective applications for drug delivery. Taylor & Francis 2020-07-22 /pmc/articles/PMC7476547/ /pubmed/32939172 http://dx.doi.org/10.1080/14686996.2020.1790032 Text en © 2020 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Bio-Inspired and Biomedical Materials
Chen, Bo-Wei
He, Yun-Chi
Sung, Shian-Ying
Le, Trang Thi Huynh
Hsieh, Chia-Ling
Chen, Jiann-Yeu
Wei, Zung-Hang
Yao, Da-Jeng
Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications
title Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications
title_full Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications
title_fullStr Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications
title_full_unstemmed Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications
title_short Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications
title_sort synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications
topic Bio-Inspired and Biomedical Materials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476547/
https://www.ncbi.nlm.nih.gov/pubmed/32939172
http://dx.doi.org/10.1080/14686996.2020.1790032
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