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Convenient access to pyrrolidin-3-ylphosphonic acids and tetrahydro-2H-pyran-3-ylphosphonates with multiple contiguous stereocenters from nonracemic adducts of a Ni(II)-catalyzed Michael reaction

A new synthetic strategy toward nonracemic phosphoryl-substituted pyrrolidines and tetrahydropyranes with three and five contiguous stereocenters is presented. Readily available β-keto phosphonates react with conjugated nitroolefins in the presence of a chiral Ni(II) complex to give nitro keto phosp...

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Detalles Bibliográficos
Autores principales:	Reznikov, Alexander N, Nikerov, Dmitry S, Sibiryakova, Anastasiya E, Rybakov, Victor B, Golovin, Evgeniy V, Klimochkin, Yuri N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2020
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476589/ https://www.ncbi.nlm.nih.gov/pubmed/32952723 http://dx.doi.org/10.3762/bjoc.16.174

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