Cargando…

Targeting 14-3-3ε-CDC25A interactions to trigger apoptotic cell death in skin cancer

Non-melanoma skin cancer is the most common form of cancer worldwide. We previously documented an anti-apoptotic role for CDC25A in cutaneous squamous cell carcinoma (SCC), an activity dependent on its association with 14-3-3 proteins. We hypothesized that targeting CDC25A-14-3-3ε interactions may b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holmes, Thomas R., Al-Matouq, Jenan, Holmes, Matti, Nicola, Lauren, Rudd, Justin C., Lovas, Sándor, Hansen, Laura A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476737/ https://www.ncbi.nlm.nih.gov/pubmed/32934772 http://dx.doi.org/10.18632/oncotarget.27700

Ejemplares similares

Optimizing Phosphopeptide Structures That Target 14-3-3ε in Cutaneous Squamous Cell Carcinoma
por: Kamayirese, Seraphine, et al.
Publicado: (2023)

The Role of 14-3-3ε Interaction with Phosphorylated Cdc25B at Its Ser321 in the Release of the Mouse Oocyte from Prophase I Arrest
por: Meng, Jun, et al.
Publicado: (2013)

Human Cdc14A Phosphatase Modulates the G2/M Transition through Cdc25A and Cdc25B
por: Vázquez-Novelle, María D., et al.
Publicado: (2010)

Integrative Role of 14-3-3ε in Sleep Regulation
por: Wei, Yu, et al.
Publicado: (2021)

Membrane structure and internalization dynamics of human Flower isoforms hFWE3 and hFWE4 indicate a conserved endocytic role for hFWE4
por: Rudd, Justin C., et al.
Publicado: (2023)

YWHA (14-3-3) protein isoforms and their interactions with CDC25B phosphatase in mouse oogenesis and oocyte maturation
por: Eisa, Alaa A., et al.
Publicado: (2019)

14-3-3ε Is Required for Germ Cell Migration in Drosophila
por: Tsigkari, K. Kirki, et al.
Publicado: (2012)

14-3-3 epsilon prevents G2/M transition of fertilized mouse eggs by binding with CDC25B
por: Cui, Cheng, et al.
Publicado: (2014)

Specificity of ε and Non-ε Isoforms of Arabidopsis 14-3-3 Proteins Towards the H(+)-ATPase and Other Targets
por: Pallucca, Roberta, et al.
Publicado: (2014)

14-3-3ε protein-loaded 3D hydrogels favor osteogenesis
por: Aldana, Ana A., et al.
Publicado: (2020)

Expression of cdc25A and cdc25B proteins in thyroid neoplasms
por: Ito, Y, et al.
Publicado: (2002)

14-3-3ε Overexpression Contributes to Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma
por: Liu, Tzu-An, et al.
Publicado: (2013)

Post-transcriptional screen of cancer amplified genes identifies ERBB2/Her2 signaling as AU-rich mRNA stability-promoting pathway
por: Al-Matouq, Jenan, et al.
Publicado: (2021)

Cdc25b and Cdc25c Differ Markedly in Their Properties as Initiators of Mitosis
por: Karlsson, Christina, et al.
Publicado: (1999)

Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects
por: Cornell, Brett, et al.
Publicado: (2016)

Human Cdc14B Promotes Progression through Mitosis by Dephosphorylating Cdc25 and Regulating Cdk1/Cyclin B Activity
por: Tumurbaatar, Indra, et al.
Publicado: (2011)

The pro-inflammatory cytokine 14-3-3ε is a ligand of CD13 in cartilage
por: Nefla, Meriam, et al.
Publicado: (2015)

Regulation of Rim4 distribution, function, and stability during meiosis by PKA, Cdc14, and 14-3-3 proteins
por: Zhang, Rudian, et al.
Publicado: (2023)

Participation of 14-3-3ε and 14-3-3ζ proteins in the phagocytosis, component of cellular immune response, in Aedes mosquito cell lines
por: Trujillo-Ocampo, Abel, et al.
Publicado: (2017)

Cdc14 in good repair
por: Short, Ben
Publicado: (2010)

Ins and outs of Cdc14
por: Leslie, Mitch
Publicado: (2010)

SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis
por: Liu, Xiaoming, et al.
Publicado: (2022)

Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528
por: Chapman, Dail E., et al.
Publicado: (2019)

The Prognostic Value of 14-3-3 Isoforms in Vulvar Squamous Cell Carcinoma Cases: 14-3-3β and ε Are Independent Prognostic Factors for These Tumors
por: Wang, Zhihui, et al.
Publicado: (2011)

Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus
por: Nishioka, K, et al.
Publicado: (2001)

cdc-25.4, a Caenorhabditis elegans Ortholog of cdc25, Is Required for Male Mating Behavior
por: Oh, Sangmi, et al.
Publicado: (2016)

Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling
por: Andrews, Daniel D. T., et al.
Publicado: (2023)

Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes
por: Wang, Zhihui, et al.
Publicado: (2010)

Homocysteine Induces Apoptosis of Rat Hippocampal Neurons by Inhibiting 14-3-3ε Expression and Activating Calcineurin
por: Wang, Jing, et al.
Publicado: (2012)

Neuroprotective Effect of TAT-14-3-3ε Fusion Protein against Cerebral Ischemia/Reperfusion Injury in Rats
por: Zhu, Yuanjun, et al.
Publicado: (2014)

The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε
por: Cao, Shengliang, et al.
Publicado: (2020)

Drosophila Activated Cdc42 Kinase Has an Anti-Apoptotic Function
por: Schoenherr, Jessica A., et al.
Publicado: (2012)

CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia
por: Bertoli, Sarah, et al.
Publicado: (2015)

Caffeine stabilizes Cdc25 independently of Rad3 in S chizosaccharomyces pombe contributing to checkpoint override
por: Alao, John P, et al.
Publicado: (2014)

Cdc25 and Wee1: analogous opposites?
por: Perry, Jennifer A, et al.
Publicado: (2007)

Prevalence of side-effects associated with the booster dose of Pfizer-BioNTech (BNT162b2) of COVID-19 Vaccine among vaccinated adults in the Eastern province of Saudi Arabia
por: Al-Matouq, Jenan Ahmed, et al.
Publicado: (2022)

Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer
por: Lozada, Enerlyn M., et al.
Publicado: (2016)

Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B
por: Muys, Bruna R., et al.
Publicado: (2023)

Cdc14p turns MEN on and off
por: Wells, William A.
Publicado: (2002)

Association of APOE Serum Levels and APOE ε2, ε3, and ε4 Alleles with Optic Neuritis
por: Momkute, Liucija, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_omt0r3grbpjmmj64l5dmbgtmat