Cargando…

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

Brown adipose tissue (BAT) is composed of thermogenic cells that convert chemical energy into heat to maintain a constant body temperature and counteract metabolic disease. The metabolic adaptations required for thermogenesis are not fully understood. Here, we explore how steady state levels of meta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Panic, Vanja, Pearson, Stephanie, Banks, James, Tippetts, Trevor S, Velasco-Silva, Jesse N, Lee, Sanghoon, Simcox, Judith, Geoghegan, Gisela, Bensard, Claire L, van Ry, Tyler, Holland, Will L, Summers, Scott A, Cox, James, Ducker, Gregory S, Rutter, Jared, Villanueva, Claudio J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476754/ https://www.ncbi.nlm.nih.gov/pubmed/32795388 http://dx.doi.org/10.7554/eLife.52558

Ejemplares similares

GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes
por: Jena, Jayashree, et al.
Publicado: (2023)

Lipid Transport in Brown Adipocyte Thermogenesis
por: Wade, Gina, et al.
Publicado: (2021)

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis
por: Galic, Sandra, et al.
Publicado: (2018)

Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis
por: Johnson, Jordan M., et al.
Publicado: (2023)

SAT430 Effect Of Organochlorine Pesticides On Brown Adipose Thermogenesis
por: Huang, Shenq-Shyang, et al.
Publicado: (2023)

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum
por: Swift, Russell P, et al.
Publicado: (2020)

Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria
por: Wang, Yingying, et al.
Publicado: (2022)

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria
por: Nowinski, Sara M, et al.
Publicado: (2020)

OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21
por: Pereira, Renata O, et al.
Publicado: (2021)

Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance
por: Tsai, Kaitlyn, et al.
Publicado: (2022)

A selective gut bacterial bile salt hydrolase alters host metabolism
por: Yao, Lina, et al.
Publicado: (2018)

Basis of specificity for a conserved and promiscuous chromatin remodeling protein
por: Donovan, Drake A, et al.
Publicado: (2021)

Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction
por: Winter, Jacob M, et al.
Publicado: (2022)

Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations
por: Cupo, Ryan R, et al.
Publicado: (2020)

ORACLE reveals a bright future to fight bacteria
por: Coyote-Maestas, Willow, et al.
Publicado: (2021)

Structural insight on the mechanism of an electron-bifurcating [FeFe] hydrogenase
por: Furlan, Chris, et al.
Publicado: (2022)

Mitochondrial Lipid Signaling and Adaptive Thermogenesis
por: Von Bank, Helaina, et al.
Publicado: (2021)

Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage
por: Wendorff, Timothy J, et al.
Publicado: (2018)

Closing the circle
por: Machingura, Marylou C, et al.
Publicado: (2018)

A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3
por: Pardal, Alonso Javier, et al.
Publicado: (2022)

DNA passes through cohesin’s hinge as well as its Smc3–kleisin interface
por: Collier, James E, et al.
Publicado: (2022)

The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader
por: Puri, Neha, et al.
Publicado: (2021)

Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells
por: Kirkemo, Lisa L, et al.
Publicado: (2022)

RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not
por: Webster, Michael W, et al.
Publicado: (2019)

Ribozyme-catalysed RNA synthesis using triplet building blocks
por: Attwater, James, et al.
Publicado: (2018)

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
por: Conlon, Erin G, et al.
Publicado: (2018)

Atomic structure of a mitochondrial complex I intermediate from vascular plants
por: Maldonado, Maria, et al.
Publicado: (2020)

The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment
por: Shi, Xiaoshan, et al.
Publicado: (2020)

Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails
por: Mattijssen, Sandy, et al.
Publicado: (2020)

Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo
por: Scotney, Hannah, et al.
Publicado: (2017)

Structural insight into toxin secretion by contact-dependent growth inhibition transporters
por: Guerin, Jeremy, et al.
Publicado: (2020)

Chemical and structural investigation of the paroxetine-human serotonin transporter complex
por: Coleman, Jonathan A, et al.
Publicado: (2020)

Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA
por: Lee, James, et al.
Publicado: (2019)

Molecular determinants of phase separation for Drosophila DNA replication licensing factors
por: Parker, Matthew W, et al.
Publicado: (2021)

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
por: Morck, Makenna M, et al.
Publicado: (2022)

DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic function
por: Jeong, Joshua, et al.
Publicado: (2022)

Characterization of pyruvate kinase from the anoxia tolerant turtle, Trachemys scripta elegans: a potential role for enzyme methylation during metabolic rate depression
por: Mattice, Amanda M.S., et al.
Publicado: (2018)

Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites
por: Falekun, Seyi, et al.
Publicado: (2021)

RNA sequence to structure analysis from comprehensive pairwise mutagenesis of multiple self-cleaving ribozymes
por: Roberts, Jessica M, et al.
Publicado: (2023)

LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection
por: Mattijssen, Sandy, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dh7vqlh3jgvbjltkv8u72mua7f