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The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs
As a rodent basal ganglia (BG) output nucleus, the substantia nigra pars reticulata (SNr) is well positioned to impact behavior. SNr neurons receive GABAergic inputs from the striatum (direct pathway) and globus pallidus (GPe, indirect pathway). Dominant theories of action selection rely on these pa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476764/ https://www.ncbi.nlm.nih.gov/pubmed/32894224 http://dx.doi.org/10.7554/eLife.55592 |
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author | Phillips, Ryan S Rosner, Ian Gittis, Aryn H Rubin, Jonathan E |
author_facet | Phillips, Ryan S Rosner, Ian Gittis, Aryn H Rubin, Jonathan E |
author_sort | Phillips, Ryan S |
collection | PubMed |
description | As a rodent basal ganglia (BG) output nucleus, the substantia nigra pars reticulata (SNr) is well positioned to impact behavior. SNr neurons receive GABAergic inputs from the striatum (direct pathway) and globus pallidus (GPe, indirect pathway). Dominant theories of action selection rely on these pathways’ inhibitory actions. Yet, experimental results on SNr responses to these inputs are limited and include excitatory effects. Our study combines experimental and computational work to characterize, explain, and make predictions about these pathways. We observe diverse SNr responses to stimulation of SNr-projecting striatal and GPe neurons, including biphasic and excitatory effects, which our modeling shows can be explained by intracellular chloride processing. Our work predicts that ongoing GPe activity could tune the SNr operating mode, including its responses in decision-making scenarios, and GPe output may modulate synchrony and low-frequency oscillations of SNr neurons, which we confirm using optogenetic stimulation of GPe terminals within the SNr. |
format | Online Article Text |
id | pubmed-7476764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-74767642020-09-09 The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs Phillips, Ryan S Rosner, Ian Gittis, Aryn H Rubin, Jonathan E eLife Neuroscience As a rodent basal ganglia (BG) output nucleus, the substantia nigra pars reticulata (SNr) is well positioned to impact behavior. SNr neurons receive GABAergic inputs from the striatum (direct pathway) and globus pallidus (GPe, indirect pathway). Dominant theories of action selection rely on these pathways’ inhibitory actions. Yet, experimental results on SNr responses to these inputs are limited and include excitatory effects. Our study combines experimental and computational work to characterize, explain, and make predictions about these pathways. We observe diverse SNr responses to stimulation of SNr-projecting striatal and GPe neurons, including biphasic and excitatory effects, which our modeling shows can be explained by intracellular chloride processing. Our work predicts that ongoing GPe activity could tune the SNr operating mode, including its responses in decision-making scenarios, and GPe output may modulate synchrony and low-frequency oscillations of SNr neurons, which we confirm using optogenetic stimulation of GPe terminals within the SNr. eLife Sciences Publications, Ltd 2020-09-07 /pmc/articles/PMC7476764/ /pubmed/32894224 http://dx.doi.org/10.7554/eLife.55592 Text en © 2020, Phillips et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Phillips, Ryan S Rosner, Ian Gittis, Aryn H Rubin, Jonathan E The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs |
title | The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs |
title_full | The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs |
title_fullStr | The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs |
title_full_unstemmed | The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs |
title_short | The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs |
title_sort | effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476764/ https://www.ncbi.nlm.nih.gov/pubmed/32894224 http://dx.doi.org/10.7554/eLife.55592 |
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