Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor

• Circuit thrombosis complicates CRRT in COVID-19 despite standard heparin-based anticoagulation regimens. • 5 cases of CRRT thrombosis despite heparin-based anticoagulation resolved using a direct thrombin inhibitor, argatroban. • Changes in fibrinogen levels better reflected response to anticoagul...

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Autores principales: Seshadri, Madhav, Ahamed, Jasimuddin, Laurence, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476895/
http://dx.doi.org/10.1016/j.tru.2020.100009
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author Seshadri, Madhav
Ahamed, Jasimuddin
Laurence, Jeffrey
author_facet Seshadri, Madhav
Ahamed, Jasimuddin
Laurence, Jeffrey
author_sort Seshadri, Madhav
collection PubMed
description • Circuit thrombosis complicates CRRT in COVID-19 despite standard heparin-based anticoagulation regimens. • 5 cases of CRRT thrombosis despite heparin-based anticoagulation resolved using a direct thrombin inhibitor, argatroban. • Changes in fibrinogen levels better reflected response to anticoagulation than did changes in D-dimer levels. • High fibrinogen levels and decreased anti-thrombin III activity may relate to argatroban superiority in these cases.
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spelling pubmed-74768952020-09-08 Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor Seshadri, Madhav Ahamed, Jasimuddin Laurence, Jeffrey Thrombosis Update Article • Circuit thrombosis complicates CRRT in COVID-19 despite standard heparin-based anticoagulation regimens. • 5 cases of CRRT thrombosis despite heparin-based anticoagulation resolved using a direct thrombin inhibitor, argatroban. • Changes in fibrinogen levels better reflected response to anticoagulation than did changes in D-dimer levels. • High fibrinogen levels and decreased anti-thrombin III activity may relate to argatroban superiority in these cases. The Author(s). Published by Elsevier Ltd. 2020-12 2020-09-08 /pmc/articles/PMC7476895/ http://dx.doi.org/10.1016/j.tru.2020.100009 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Seshadri, Madhav
Ahamed, Jasimuddin
Laurence, Jeffrey
Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor
title Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor
title_full Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor
title_fullStr Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor
title_full_unstemmed Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor
title_short Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor
title_sort intervention in covid-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476895/
http://dx.doi.org/10.1016/j.tru.2020.100009
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AT laurencejeffrey interventionincovid19linkedhypercoaguablestatescharacterizedbycircuitthrombosisutilizingadirectthrombininhibitor

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