Cargando…

Efficacy of GAD-alum immunotherapy associated with HLA-DR3-DQ2 in recently diagnosed type 1 diabetes

AIMS/HYPOTHESIS: The aim of this study was to determine if retention of C-peptide following immunotherapy using recombinant GAD65 conjugated to aluminium hydroxide (GAD-alum) is influenced by HLA risk haplotypes DR3-DQ2 and DR4-DQ8. METHODS: HLA-dependent treatment effect of GAD-alum therapy on C-pe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hannelius, Ulf, Beam, Craig A., Ludvigsson, Johnny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476912/ https://www.ncbi.nlm.nih.gov/pubmed/32754804 http://dx.doi.org/10.1007/s00125-020-05227-z

Ejemplares similares

Intralymphatic GAD-Alum (Diamyd®) Improves Glycemic Control in Type 1 Diabetes With HLA DR3-DQ2
por: Nowak, Christoph, et al.
Publicado: (2022)

Association between treatment effect on C‐peptide preservation and HbA1c in meta‐analysis of glutamic acid decarboxylase (GAD)‐alum immunotherapy in recent‐onset type 1 diabetes
por: Nowak, Christoph, et al.
Publicado: (2022)

Phase III, randomised, double-blind, placebo-controlled, multicentre trial to evaluate the efficacy and safety of rhGAD65 to preserve endogenous beta cell function in adolescents and adults with recently diagnosed type 1 diabetes, carrying the genetic HLA DR3-DQ2 haplotype: the DIAGNODE-3 study protocol
por: Ludvigsson, Johnny, et al.
Publicado: (2022)

Effect of simultaneous vaccination with H1N1 and GAD-alum on GAD(65)-induced immune response
por: Tavira, Beatriz, et al.
Publicado: (2017)

GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells
por: Arif, Sefina, et al.
Publicado: (2020)

Long-Lasting Immune Responses 4 Years after GAD-Alum Treatment in Children with Type 1 Diabetes
por: Axelsson, Stina, et al.
Publicado: (2011)

Cellular and Humoral Immune Responses in Type 1 Diabetic Patients Participating in a Phase III GAD-alum Intervention Trial
por: Axelsson, Stina, et al.
Publicado: (2013)

Intralymphatic GAD-alum Injection Modulates B Cell Response and Induces Follicular Helper T Cells and PD-1+ CD8+ T Cells in Patients With Recent-Onset Type 1 Diabetes
por: Barcenilla, Hugo, et al.
Publicado: (2022)

Latent Autoimmune Diabetes in Adults: Background, Safety and Feasibility of an Ongoing Pilot Study With Intra-Lymphatic Injections of GAD-Alum and Oral Vitamin D
por: Björklund, Anneli, et al.
Publicado: (2022)

Peptide binding predictions for HLA DR, DP and DQ molecules
por: Wang, Peng, et al.
Publicado: (2010)

Association of HLA-DR/DQ polymorphisms with schizophrenia in Tunisian patients
por: Sayeh, Aicha, et al.
Publicado: (2014)

Immunogenetic Study of Diabetes Mellitus in Relation to HLA DQ and DR
por: Singh, Gyanendra, et al.
Publicado: (2020)

Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children
por: Zhao, Lue Ping, et al.
Publicado: (2020)

Intra-lymphatic administration of GAD-alum in type 1 diabetes: long-term follow-up and effect of a late booster dose (the DIAGNODE Extension trial)
por: Casas, Rosaura, et al.
Publicado: (2022)

Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients
por: Kovalchuka, Lilija, et al.
Publicado: (2012)

The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ
por: Basturk, Ahmet, et al.
Publicado: (2017)

HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation
por: Murad, Hossam, et al.
Publicado: (2018)

Combined vitamin D, ibuprofen and glutamic acid decarboxylase-alum treatment in recent onset Type I diabetes: lessons from the DIABGAD randomized pilot trial
por: Ludvigsson, Johnny, et al.
Publicado: (2020)

HLA‐DR/DQ molecular mismatch: A prognostic biomarker for primary alloimmunity
por: Wiebe, Chris, et al.
Publicado: (2018)

HLA-DR and HLA-DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance
por: da Silva, Samira A, et al.
Publicado: (2009)

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ
por: Hrdinová, Johana, et al.
Publicado: (2018)

HLA-DQ-Specific Recombinant Human Monoclonal Antibodies Allow for In-Depth Analysis of HLA-DQ Epitopes
por: Bezstarosti, Suzanne, et al.
Publicado: (2022)

Nine residues in HLA-DQ molecules determine with susceptibility and resistance to type 1 diabetes among young children in Sweden
por: Zhao, Lue Ping, et al.
Publicado: (2021)

Human hematopoietic progenitor cells in long-term cultures express HLA- DR antigens and lack HLA-DQ antigens
Publicado: (1985)

The HLA-B*3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes
por: Baschal, E. E., et al.
Publicado: (2011)

Comparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells
por: Peyron, Ivan, et al.
Publicado: (2018)

HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity
por: Lundgren, Hanna, et al.
Publicado: (2017)

Glysters of Alum for Dysentery, by Dr. Hamon
Publicado: (1858)

Assessing the Prevalence of HLA-DQ2 and HLA-DQ8 in Lipedema Patients and the Potential Benefits of a Gluten-Free Diet
por: Amato, Alexandre C, et al.
Publicado: (2023)

THE PREVALENCE OF HLA DQ2 AND DQ8 IN PATIENTS WITH CELIAC DISEASE, IN FAMILY AND IN GENERAL POPULATION
por: CECILIO, Lucila Arantes, et al.
Publicado: (2015)

Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease
por: Aboulaghras, Sara, et al.
Publicado: (2023)

The association of HLA-DR/DQ coding and QBP promoter allelic polymorphism with antiphospholipid antibody response in SLE
por: Logar, D, et al.
Publicado: (2002)

HLA class I (-A, -B, -C) and class II (-DR, -DQ) polymorphism in the Mauritanian population
por: Hamed, Cheikh Tijani, et al.
Publicado: (2018)

The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype
por: Reinauer, Christina, et al.
Publicado: (2017)

Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma
por: Knutsen, Alan P, et al.
Publicado: (2010)

Definition of High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Types Using Only Three Single Nucleotide Polymorphisms
por: Nguyen, Cao, et al.
Publicado: (2013)

Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition
Publicado: (1990)

Intralymphatic glutamic acid decarboxylase administration in type 1 diabetes patients induced a distinctive early immune response in patients with DR3DQ2 haplotype
por: Puente-Marin, Sara, et al.
Publicado: (2023)

Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study
por: Delli, Ahmed J., et al.
Publicado: (2012)

Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden
por: Carlsson, A, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_5m53opphh0p916ke34v6g13sep