Cargando…

Stirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells

Due to their ability to standardize key physiological parameters, stirred suspension bioreactors can potentially scale the production of quality-controlled pluripotent stem cells (PSCs) for cell therapy application. Because of differences in bioreactor expansion efficiency between mouse (m) and huma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rohani, Leili, Borys, Breanna S., Razian, Golsa, Naghsh, Pooyan, Liu, Shiying, Johnson, Adiv A., Machiraju, Pranav, Holland, Heidrun, Lewis, Ian A., Groves, Ryan A., Toms, Derek, Gordon, Paul M. K., Li, Joyce W., So, Tania, Dang, Tiffany, Kallos, Michael S., Rancourt, Derrick E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476926/ https://www.ncbi.nlm.nih.gov/pubmed/32895477 http://dx.doi.org/10.1038/s42003-020-01218-3

Ejemplares similares

Concise Review: Molecular Cytogenetics and Quality Control: Clinical Guardians for Pluripotent Stem Cells
por: Rohani, Leili, et al.
Publicado: (2018)

An Integrated Approach toward the Biomanufacturing of Engineered Cell Therapy Products in a Stirred-Suspension Bioreactor
por: Hsu, Charlie Y.M., et al.
Publicado: (2018)

Overcoming bioprocess bottlenecks in the large-scale expansion of high-quality hiPSC aggregates in vertical-wheel stirred suspension bioreactors
por: Borys, Breanna S., et al.
Publicado: (2021)

Optimized serial expansion of human induced pluripotent stem cells using low‐density inoculation to generate clinically relevant quantities in vertical‐wheel bioreactors
por: Borys, Breanna S., et al.
Publicado: (2020)

The aging signature: a hallmark of induced pluripotent stem cells?
por: Rohani, Leili, et al.
Publicado: (2014)

Enhanced Expansion and Sustained Inductive Function of Skin‐Derived Precursor Cells in Computer‐Controlled Stirred Suspension Bioreactors
por: Agabalyan, Natacha A., et al.
Publicado: (2016)

Enhanced Osteogenic Differentiation of Pluripotent Stem Cells via γ-Secretase Inhibition
por: Helmi, Summer A., et al.
Publicado: (2021)

Cell-Based Therapy Manufacturing in Stirred Suspension Bioreactor: Thoughts for cGMP Compliance
por: Nath, Suman C., et al.
Publicado: (2020)

Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
por: Lee, Brian, et al.
Publicado: (2020)

Impact of stirred suspension bioreactor culture on the differentiation of murine embryonic stem cells into cardiomyocytes
por: Shafa, Mehdi, et al.
Publicado: (2011)

Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytes
por: Machiraju, Pranav, et al.
Publicado: (2019)

Core–shell hydrogel microcapsules enable formation of human pluripotent stem cell spheroids and their cultivation in a stirred bioreactor
por: Fattahi, Pouria, et al.
Publicado: (2021)

The Proliferation of Pre-Pubertal Porcine Spermatogonia in Stirred Suspension Bioreactors Is Partially Mediated by the Wnt/β-Catenin Pathway
por: Sakib, Sadman, et al.
Publicado: (2021)

Process control and in silico modeling strategies for enabling high density culture of human pluripotent stem cells in stirred tank bioreactors
por: Manstein, Felix, et al.
Publicado: (2021)

Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
por: Lee, Brian, et al.
Publicado: (2022)

Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells
por: Yamashita, Akihiro, et al.
Publicado: (2013)

Improved expansion of equine cord blood derived mesenchymal stromal cells by using microcarriers in stirred suspension bioreactors
por: Roberts, Erin L., et al.
Publicado: (2019)

Optical stirring in a droplet cell bioreactor
por: Muradoglu, Murat, et al.
Publicado: (2012)

Production of Large Numbers of Size-controlled Tumor Spheroids Using Microwell Plates
por: Razian, Golsa, et al.
Publicado: (2013)

Production of bioherbicide by Phoma sp. in a stirred-tank bioreactor
por: Brun, Thiarles, et al.
Publicado: (2016)

Power Input Measurements in Stirred Bioreactors at Laboratory Scale
por: Kaiser, Stephan C., et al.
Publicado: (2018)

On the fluid dynamics of a laboratory scale single-use stirred bioreactor
por: Odeleye, A.O.O., et al.
Publicado: (2014)

Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors
por: Eicke, Dorothee, et al.
Publicado: (2018)

Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors
por: Schwedhelm, Ivo, et al.
Publicado: (2019)

Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors
por: Gallego‐Murillo, Joan Sebastián, et al.
Publicado: (2022)

Single-Use Bioreactors for Human Pluripotent and Adult Stem Cells: Towards Regenerative Medicine Applications
por: Nogueira, Diogo E.S., et al.
Publicado: (2021)

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells
por: Przepiorski, Aneta, et al.
Publicado: (2018)

Evaluation of a disposable stirred tank bioreactor for cultivation of mammalian cells
por: Hähnel, Alexander, et al.
Publicado: (2011)

Production of Calcaride A by Calcarisporium sp. in Shaken Flasks and Stirred Bioreactors
por: Tamminen, Anu, et al.
Publicado: (2015)

Oxygen Transport and Stem Cell Aggregation in Stirred-Suspension Bioreactor Cultures
por: Wu, Jincheng, et al.
Publicado: (2014)

The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors
por: Bayley, Rachel, et al.
Publicado: (2017)

Induced pluripotency in the context of stem cell expansion bioprocess development, optimization, and manufacturing: a roadmap to the clinic
por: Colter, James, et al.
Publicado: (2021)

Modulation of Reoviral Cytolysis (II): Cellular Stemness
por: Bourhill, Tarryn, et al.
Publicado: (2023)

Strategies for the expansion of human induced pluripotent stem cells as aggregates in single-use Vertical-Wheel™ bioreactors
por: Nogueira, Diogo E. S., et al.
Publicado: (2019)

Human pluripotent stem cell process parameter optimization in a small scale suspension bioreactor
por: Lipsitz, Yonatan Y, et al.
Publicado: (2015)

Combining Hypoxia and Bioreactor Hydrodynamics Boosts Induced Pluripotent Stem Cell Differentiation Towards Cardiomyocytes
por: Correia, Cláudia, et al.
Publicado: (2014)

Effect of inoculum density on human‐induced pluripotent stem cell expansion in 3D bioreactors
por: Greuel, Selina, et al.
Publicado: (2019)

Characterization and performance of the Allegro™ STR 200 single-use stirred tank bioreactor
por: Rees, Byron, et al.
Publicado: (2015)

An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes
por: Schirmer, Cedric, et al.
Publicado: (2021)

Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor
por: Freyer, Nora, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_caeio3ls9maiq6nds7dfndmso3