Cargando…

Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19

COVID-19 caused by the novel SARS-CoV-2 has been declared a pandemic by the WHO is causing havoc across the entire world. As of May end, about 6 million people have been affected, and 367 166 have died from COVID-19. Recent studies suggest that the SARS-CoV-2 genome shares about 80% similarity with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Faheem, Kumar, Banoth Karan, Sekhar, Kondapalli Venkata Gowri Chandra, Kunjiappan, Selvaraj, Jamalis, Joazaizulfazli, Balaña-Fouce, Rafael, Tekwani, Babu L., Sankaranarayanan, Murugesan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2020
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476961/ https://www.ncbi.nlm.nih.gov/pubmed/32947136 http://dx.doi.org/10.1016/j.bioorg.2020.104269

Ejemplares similares

Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies
por: Faheem,, et al.
Publicado: (2021)

Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives – An update
por: Banoth, Karan Kumar, et al.
Publicado: (2020)

Synthesis, study of antileishmanial and antitrypanosomal activity of imidazo pyridine fused triazole analogues
por: Nandikolla, Adinarayana, et al.
Publicado: (2020)

Design, synthesis and biological evaluation of benzo-[d]-imidazo-[2,1-b]-thiazole and imidazo-[2,1-b]-thiazole carboxamide triazole derivatives as antimycobacterial agents
por: Chitti, Surendar, et al.
Publicado: (2022)

l-Ornithine-N5-monooxygenase (PvdA) Substrate Analogue Inhibitors for Pseudomonas aeruginosa Infections Treatment: Drug Repurposing Computational Studies
por: Rosy, Joseph Christina, et al.
Publicado: (2022)

Inhibitors of pantothenate synthetase of Mycobacterium tuberculosis – a medicinal chemist perspective
por: Suresh, Amaroju, et al.
Publicado: (2020)

Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in Pseudomonas aeruginosa
por: Srinivasarao, Singireddi, et al.
Publicado: (2019)

Graph theoretical network analysis, in silico exploration, and validation of bioactive compounds from Cynodon dactylon as potential neuroprotective agents against α-synuclein
por: Rajeshkumar, Raja Rajeswari, et al.
Publicado: (2022)

Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria
por: Álvarez-Bardón, María, et al.
Publicado: (2020)

Design, Synthesis, and Biological Evaluation of Novel Quinazolin-4(3H)-One-Based Histone Deacetylase 6 (HDAC6) Inhibitors for Anticancer Activity
por: Khetmalis, Yogesh Mahadu, et al.
Publicado: (2023)

Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents
por: Srinivasarao, Singireddi, et al.
Publicado: (2020)

Correction: Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents
por: Srinivasarao, Singireddi, et al.
Publicado: (2020)

Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties
por: Jamalis, Joazaizulfazli, et al.
Publicado: (2020)

Liposomes: An emerging carrier for targeting Alzheimer's and Parkinson's diseases()
por: Pandian, Sureshbabu Ram Kumar, et al.
Publicado: (2022)

Recent Progress in Synthesis, POM Analyses and SAR of Coumarin-Hybrids as Potential Anti-HIV Agents—A Mini Review
por: Suleiman, Mustapha, et al.
Publicado: (2023)

Discovery of Novel Coumarin-Schiff Base Hybrids as Potential Acetylcholinesterase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Computational Studies
por: Hasan, Aso Hameed, et al.
Publicado: (2023)

Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates
por: García-Estrada, Carlos, et al.
Publicado: (2023)

Pyridine- and Thiazole-Based Hydrazides with Promising Anti-inflammatory and Antimicrobial Activities along with Their In Silico Studies
por: Kamat, Vinuta, et al.
Publicado: (2020)

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications
por: Rajagopal, Gopalan, et al.
Publicado: (2021)

Pharmacoinformatics-Based Approach for Uncovering the Quorum-Quenching Activity of Phytocompounds against the Oral Pathogen, Streptococcus mutans
por: Marimuthu, Shakti Chandra Vadhana, et al.
Publicado: (2023)

Identification of Papain-Like Protease inhibitors of SARS CoV-2 through HTVS, Molecular docking, MMGBSA and Molecular dynamics approach
por: Jupudi, Srikanth, et al.
Publicado: (2022)

Potential inhibitory activity of phytoconstituents against black fungus: In silico ADMET, molecular docking and MD simulation studies
por: Hamaamin Hussen, Narmin, et al.
Publicado: (2022)

(E)-3-(3-Methylthiophen-2-yl)-1-p-tolylprop-2-en-1-one. Corrigendum
por: Naveen, S., et al.
Publicado: (2021)

Functional Expression of a DNA-Topoisomerase IB from Cryptosporidium parvum
por: Ordóñez, César, et al.
Publicado: (2009)

Pharmacoinformatics-based investigation of bioactive compounds of Rasam (South Indian recipe) against human cancer
por: Kalimuthu, Arjun Kumar, et al.
Publicado: (2021)

Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity
por: Lu, Bin, et al.
Publicado: (2021)

One-pot synthesis, molecular docking, ADMET, and DFT studies of novel pyrazolines as promising SARS-CoV-2 main protease inhibitors
por: Salih, Rezan Huseen Hama, et al.
Publicado: (2022)

Scanning Electron Microscopes/Silicon Drift Detector-Energy Dispersive Spectroscopy: An Analytical Tool to Identify Waterborne Microminerals Pickup in Human Scalp Hair Cuticle due to Water Quality
por: Somasundaram, Balasubramanian, et al.
Publicado: (2018)

The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets
por: Lago, Santiago G., et al.
Publicado: (2022)

Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania major
por: Balaña-Fouce, Rafael, et al.
Publicado: (2008)

Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?
por: Reguera, Rosa M., et al.
Publicado: (2014)

Zoonotic Implications of Onchocerca Species on Human Health
por: Cambra-Pellejà, Maria, et al.
Publicado: (2020)

Deletion Study of DNA Topoisomerase IB from Leishmania donovani: Searching for a Minimal Functional Heterodimer
por: Díaz González, Rosario, et al.
Publicado: (2007)

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
por: Gaziano, Liam, et al.
Publicado: (2021)

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery
por: Balaña-Fouce, Rafael, et al.
Publicado: (2014)

Functional and druggability analysis of the SARS-CoV-2 proteome
por: Cavasotto, Claudio N., et al.
Publicado: (2021)

Is the Stalk of the SARS-CoV-2 Spike Protein Druggable?
por: Pipitò, Ludovico, et al.
Publicado: (2022)

Effect of level of infection by gastrointestinal nematodes and anthelmintic treatment on milk yield in dairy sheep
por: Martínez-Valladares, María, et al.
Publicado: (2021)

KRAS: Druggable at Last
por: Herzberg, Benjamin O, et al.
Publicado: (2023)

Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin
por: Carballeira, Néstor M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_1tp1o2m93t24fmilgr70i2pv31