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Prevalence of potential drug–drug interactions in outpatients of a general hospital in China: a retrospective investigation

Background Potential drug–drug interactions are important factors resulting in adverse drug reactions or therapeutic failure. Therefore, potential drug–drug interactions need to be identified to prevent the related risk and improve drug safety. Objective This study was designed to determine the prev...

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Autores principales: Ren, Weifang, Liu, Yujuan, Zhang, Jun, Fang, Zhonghong, Fang, Huan, Gong, Yuan, Lv, Xiaoqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476976/
https://www.ncbi.nlm.nih.gov/pubmed/32488437
http://dx.doi.org/10.1007/s11096-020-01068-3
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author Ren, Weifang
Liu, Yujuan
Zhang, Jun
Fang, Zhonghong
Fang, Huan
Gong, Yuan
Lv, Xiaoqun
author_facet Ren, Weifang
Liu, Yujuan
Zhang, Jun
Fang, Zhonghong
Fang, Huan
Gong, Yuan
Lv, Xiaoqun
author_sort Ren, Weifang
collection PubMed
description Background Potential drug–drug interactions are important factors resulting in adverse drug reactions or therapeutic failure. Therefore, potential drug–drug interactions need to be identified to prevent the related risk and improve drug safety. Objective This study was designed to determine the prevalence of potential drug–drug interactions and investigate the association of potential drug–drug interactions with characteristics in outpatient prescriptions. Setting A large-scale general university hospital in Jinshan District of Shanghai, China. Method The retrospective study was conducted on data obtained from prescriptions containing two or more drugs, written for outpatients older than 18 years. They were screened for potential drug–drug interactions using Lexi-Interact in UpToDate, Stockley’s Drug Interactions and Medicine Specification in the order of priority. Main outcome measure Drug–drug interactions with C, D, X risk rating and clinical parameters recorded at the prescriptions. Results 16,120 prescriptions were screened for the presence of potential drug–drug interactions and 4882 (30.29%) prescriptions containing 6667 potential drug–drug interactions were identified. Among 6667 potential drug–drug interactions, 90.81% (6054/6667), 8.49% (566/6667), 0.70% (47/6667) potential drug–drug interactions belonged to the risk category of C, D and X, respectively. Male, old age and polypharmacy increased the likelihood of potential drug–drug interactions. The most frequently prescribed drugs responsible for potential drug–drug interactions included pioglitazone, dihydrocodeine, thalidomide, sotalol, amiodarone and amlodipine. The predominant potential adverse outcome of potential drug–drug interactions was the increased central nervous system suppression function with the mechanism of reinforced pharmacological effects. Conclusion This study showed that potentially significant drug–drug interactions in outpatients were prevalent in real-world practice. Considering the risk of potential clinical consequences related to potential drug–drug interactions, it is necessary to implement the computerized surveillance and warning systems with drug–drug interactions databases as well as develop the clinical guidelines regarding the widespread potential drug–drug interactions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11096-020-01068-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-74769762020-09-21 Prevalence of potential drug–drug interactions in outpatients of a general hospital in China: a retrospective investigation Ren, Weifang Liu, Yujuan Zhang, Jun Fang, Zhonghong Fang, Huan Gong, Yuan Lv, Xiaoqun Int J Clin Pharm Research Article Background Potential drug–drug interactions are important factors resulting in adverse drug reactions or therapeutic failure. Therefore, potential drug–drug interactions need to be identified to prevent the related risk and improve drug safety. Objective This study was designed to determine the prevalence of potential drug–drug interactions and investigate the association of potential drug–drug interactions with characteristics in outpatient prescriptions. Setting A large-scale general university hospital in Jinshan District of Shanghai, China. Method The retrospective study was conducted on data obtained from prescriptions containing two or more drugs, written for outpatients older than 18 years. They were screened for potential drug–drug interactions using Lexi-Interact in UpToDate, Stockley’s Drug Interactions and Medicine Specification in the order of priority. Main outcome measure Drug–drug interactions with C, D, X risk rating and clinical parameters recorded at the prescriptions. Results 16,120 prescriptions were screened for the presence of potential drug–drug interactions and 4882 (30.29%) prescriptions containing 6667 potential drug–drug interactions were identified. Among 6667 potential drug–drug interactions, 90.81% (6054/6667), 8.49% (566/6667), 0.70% (47/6667) potential drug–drug interactions belonged to the risk category of C, D and X, respectively. Male, old age and polypharmacy increased the likelihood of potential drug–drug interactions. The most frequently prescribed drugs responsible for potential drug–drug interactions included pioglitazone, dihydrocodeine, thalidomide, sotalol, amiodarone and amlodipine. The predominant potential adverse outcome of potential drug–drug interactions was the increased central nervous system suppression function with the mechanism of reinforced pharmacological effects. Conclusion This study showed that potentially significant drug–drug interactions in outpatients were prevalent in real-world practice. Considering the risk of potential clinical consequences related to potential drug–drug interactions, it is necessary to implement the computerized surveillance and warning systems with drug–drug interactions databases as well as develop the clinical guidelines regarding the widespread potential drug–drug interactions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11096-020-01068-3) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-06-03 2020 /pmc/articles/PMC7476976/ /pubmed/32488437 http://dx.doi.org/10.1007/s11096-020-01068-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ren, Weifang
Liu, Yujuan
Zhang, Jun
Fang, Zhonghong
Fang, Huan
Gong, Yuan
Lv, Xiaoqun
Prevalence of potential drug–drug interactions in outpatients of a general hospital in China: a retrospective investigation
title Prevalence of potential drug–drug interactions in outpatients of a general hospital in China: a retrospective investigation
title_full Prevalence of potential drug–drug interactions in outpatients of a general hospital in China: a retrospective investigation
title_fullStr Prevalence of potential drug–drug interactions in outpatients of a general hospital in China: a retrospective investigation
title_full_unstemmed Prevalence of potential drug–drug interactions in outpatients of a general hospital in China: a retrospective investigation
title_short Prevalence of potential drug–drug interactions in outpatients of a general hospital in China: a retrospective investigation
title_sort prevalence of potential drug–drug interactions in outpatients of a general hospital in china: a retrospective investigation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476976/
https://www.ncbi.nlm.nih.gov/pubmed/32488437
http://dx.doi.org/10.1007/s11096-020-01068-3
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