Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes

AIMS/HYPOTHESIS: IRS2 is an important molecular switch that mediates insulin signalling in the liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigenetic mechanisms are involved in the regulation of...

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Detalles Bibliográficos
Autores principales: Krause, Christin, Geißler, Cathleen, Tackenberg, Heidi, El Gammal, Alexander T., Wolter, Stefan, Spranger, Joachim, Mann, Oliver, Lehnert, Hendrik, Kirchner, Henriette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476982/
https://www.ncbi.nlm.nih.gov/pubmed/32710190
http://dx.doi.org/10.1007/s00125-020-05212-6

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