Development of a pro-arrhythmic ex vivo intact human and porcine model: cardiac electrophysiological changes associated with cellular uncoupling

We describe a human and large animal Langendorff experimental apparatus for live electrophysiological studies and measure the electrophysiological changes due to gap junction uncoupling in human and porcine hearts. The resultant ex vivo intact human and porcine model can bridge the translational gap...

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Detalles Bibliográficos
Autores principales: Brook, Joseph, Kim, Min-young, Koutsoftidis, Simos, Pitcher, David, Agha-Jaffar, Danya, Sufi, Annam, Jenkins, Catherine, Tzortzis, Konstantinos, Ma, Suofeiya, Jabbour, Richard J., Houston, Charles, Handa, Balvinder S., Li, Xinyang, Chow, Ji-Jian, Jothidasan, Anand, Bristow, Poppy, Perkins, Justin, Harding, Sian, Bharath, Anil A, Ng, Fu Siong, Peters, Nicholas S, Cantwell, Chris D, Chowdhury, Rasheda A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Integrative Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476990/
https://www.ncbi.nlm.nih.gov/pubmed/32870378
http://dx.doi.org/10.1007/s00424-020-02446-6

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