The making of insulin in health and disease

The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and...

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Autores principales: Vasiljević, Jovana, Torkko, Juha M., Knoch, Klaus-Peter, Solimena, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476993/
https://www.ncbi.nlm.nih.gov/pubmed/32894308
http://dx.doi.org/10.1007/s00125-020-05192-7
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author Vasiljević, Jovana
Torkko, Juha M.
Knoch, Klaus-Peter
Solimena, Michele
author_facet Vasiljević, Jovana
Torkko, Juha M.
Knoch, Klaus-Peter
Solimena, Michele
author_sort Vasiljević, Jovana
collection PubMed
description The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes. [Figure: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-020-05192-7) contains a slideset of the figures for download, which is available to authorised users.
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spelling pubmed-74769932020-09-21 The making of insulin in health and disease Vasiljević, Jovana Torkko, Juha M. Knoch, Klaus-Peter Solimena, Michele Diabetologia Review The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes. [Figure: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-020-05192-7) contains a slideset of the figures for download, which is available to authorised users. Springer Berlin Heidelberg 2020-09-07 2020 /pmc/articles/PMC7476993/ /pubmed/32894308 http://dx.doi.org/10.1007/s00125-020-05192-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Vasiljević, Jovana
Torkko, Juha M.
Knoch, Klaus-Peter
Solimena, Michele
The making of insulin in health and disease
title The making of insulin in health and disease
title_full The making of insulin in health and disease
title_fullStr The making of insulin in health and disease
title_full_unstemmed The making of insulin in health and disease
title_short The making of insulin in health and disease
title_sort making of insulin in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476993/
https://www.ncbi.nlm.nih.gov/pubmed/32894308
http://dx.doi.org/10.1007/s00125-020-05192-7
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