Cargando…

An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1

INTRODUCTION: The replenishment of skin lipids depleted in the dry skin state is a desirable therapeutic target to restore skin moisturization; however, there is limited evidence demonstrating the success of this approach through the use of topical emollients. The purpose of this study was to provid...

Descripción completa

Detalles Bibliográficos
Autores principales: Danby, Simon G., Andrew, Paul V., Brown, Kirsty, Chittock, John, Kay, Linda J., Cork, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477057/
https://www.ncbi.nlm.nih.gov/pubmed/32671664
http://dx.doi.org/10.1007/s13555-020-00426-3
_version_ 1783579815186530304
author Danby, Simon G.
Andrew, Paul V.
Brown, Kirsty
Chittock, John
Kay, Linda J.
Cork, Michael J.
author_facet Danby, Simon G.
Andrew, Paul V.
Brown, Kirsty
Chittock, John
Kay, Linda J.
Cork, Michael J.
author_sort Danby, Simon G.
collection PubMed
description INTRODUCTION: The replenishment of skin lipids depleted in the dry skin state is a desirable therapeutic target to restore skin moisturization; however, there is limited evidence demonstrating the success of this approach through the use of topical emollients. The purpose of this study was to provide evidence of the benefits of a cream and equivalent lotion containing skin lipids in a multi-vesicular emulsion for the management of dry skin. The hypothesis was that the test cream and test lotion could sustain skin moisturization for longer than traditional emollients by sustainably delivering skin lipids. METHODS: A double-blind intra-subject vehicle-controlled single open-application test on the lower legs in people with dry, atopic dermatitis (atopic eczema)-prone, skin was conducted. There were six treatment sites, three per lower leg in each participant, which were treated with the test cream, the test lotion, three reference creams commonly prescribed in the UK and no treatment as a control. After baseline measurements of skin hydration, 100 μl of the test/reference creams was applied to each of the relevant treatment sites (random site allocation). Following treatment, measurements of skin hydration and scoring of visual dryness was conducted at timed intervals (3, 6, 12 and 24 h post-product application). RESULTS: The test cream and lotion both significantly increased skin hydration and reduced skin dryness for at least 24 h following a single application compared to a no treatment control site. Compared to three reference emollient creams the test cream and test lotion were the only products capable of sustaining clinically meaningful improvements in skin moisturization for 24 h. CONCLUSION: The sustained moisturization imparted by the test products reduces the need for frequent emollient application, often requiring 3–4 applications per day for traditional emollients, and should reduce the high burden of managing dry skin conditions like atopic dermatitis.
format Online
Article
Text
id pubmed-7477057
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer Healthcare
record_format MEDLINE/PubMed
spelling pubmed-74770572020-09-18 An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1 Danby, Simon G. Andrew, Paul V. Brown, Kirsty Chittock, John Kay, Linda J. Cork, Michael J. Dermatol Ther (Heidelb) Original Research INTRODUCTION: The replenishment of skin lipids depleted in the dry skin state is a desirable therapeutic target to restore skin moisturization; however, there is limited evidence demonstrating the success of this approach through the use of topical emollients. The purpose of this study was to provide evidence of the benefits of a cream and equivalent lotion containing skin lipids in a multi-vesicular emulsion for the management of dry skin. The hypothesis was that the test cream and test lotion could sustain skin moisturization for longer than traditional emollients by sustainably delivering skin lipids. METHODS: A double-blind intra-subject vehicle-controlled single open-application test on the lower legs in people with dry, atopic dermatitis (atopic eczema)-prone, skin was conducted. There were six treatment sites, three per lower leg in each participant, which were treated with the test cream, the test lotion, three reference creams commonly prescribed in the UK and no treatment as a control. After baseline measurements of skin hydration, 100 μl of the test/reference creams was applied to each of the relevant treatment sites (random site allocation). Following treatment, measurements of skin hydration and scoring of visual dryness was conducted at timed intervals (3, 6, 12 and 24 h post-product application). RESULTS: The test cream and lotion both significantly increased skin hydration and reduced skin dryness for at least 24 h following a single application compared to a no treatment control site. Compared to three reference emollient creams the test cream and test lotion were the only products capable of sustaining clinically meaningful improvements in skin moisturization for 24 h. CONCLUSION: The sustained moisturization imparted by the test products reduces the need for frequent emollient application, often requiring 3–4 applications per day for traditional emollients, and should reduce the high burden of managing dry skin conditions like atopic dermatitis. Springer Healthcare 2020-07-15 /pmc/articles/PMC7477057/ /pubmed/32671664 http://dx.doi.org/10.1007/s13555-020-00426-3 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research
Danby, Simon G.
Andrew, Paul V.
Brown, Kirsty
Chittock, John
Kay, Linda J.
Cork, Michael J.
An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1
title An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1
title_full An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1
title_fullStr An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1
title_full_unstemmed An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1
title_short An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1
title_sort investigation of the skin barrier restoring effects of a cream and lotion containing ceramides in a multi-vesicular emulsion in people with dry, eczema-prone, skin: the restore study phase 1
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477057/
https://www.ncbi.nlm.nih.gov/pubmed/32671664
http://dx.doi.org/10.1007/s13555-020-00426-3
work_keys_str_mv AT danbysimong aninvestigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT andrewpaulv aninvestigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT brownkirsty aninvestigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT chittockjohn aninvestigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT kaylindaj aninvestigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT corkmichaelj aninvestigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT danbysimong investigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT andrewpaulv investigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT brownkirsty investigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT chittockjohn investigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT kaylindaj investigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1
AT corkmichaelj investigationoftheskinbarrierrestoringeffectsofacreamandlotioncontainingceramidesinamultivesicularemulsioninpeoplewithdryeczemaproneskintherestorestudyphase1