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Association of Dopamine D2 Receptor Gene Polymorphisms with Reproduction Traits in Domestic Pigeons (Columba livia)

Dopamine inhibited prolactin secretion via dopamine D2 receptor (DRD2) at the pituitary level, but its effects on reproduction in pigeons are unclear. In this study, Single Nucleotide Polymorphisms (SNPs) in the exons of DRD2 gene were identified and analyzed by using DNA sequencing methods in 60 fe...

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Autores principales: Yin, Zhaozheng, Dong, Xinyang, Ma, Youzhi, Dong, Dingjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Poultry Science Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477188/
https://www.ncbi.nlm.nih.gov/pubmed/32908403
http://dx.doi.org/10.2141/jpsa.0160037
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author Yin, Zhaozheng
Dong, Xinyang
Ma, Youzhi
Dong, Dingjuan
author_facet Yin, Zhaozheng
Dong, Xinyang
Ma, Youzhi
Dong, Dingjuan
author_sort Yin, Zhaozheng
collection PubMed
description Dopamine inhibited prolactin secretion via dopamine D2 receptor (DRD2) at the pituitary level, but its effects on reproduction in pigeons are unclear. In this study, Single Nucleotide Polymorphisms (SNPs) in the exons of DRD2 gene were identified and analyzed by using DNA sequencing methods in 60 female domestic pigeons (Columba livia), and the association between DRD2 polymorphisms and reproduction traits was also analyzed. Sequencing results showed that 7 nucleotide mutations were detected in the exon 1, 4, and 6 regions of DRD2 gene. The analysis revealed three genotypes (AA, AB, and BB) in exon 4 and two genotypes (AA, AB) in exon 6, in which the AA genotype was consistently dominant, and the A allele showed a dominant advantage. The C4532T genotypes located in exon 6 of DRD2 gene were significantly (P<0.05) associated with reproductive traits of pigeon. Moreover, the individuals with AB genotype had significantly higher fertility rate and total hatching number within 500 days of age than those with AA genotype (P<0.05). These findings suggested that the DRD2 gene should be included in future genetic studies of pigeon reproduction and the SNP of C4532T might be a potential candidate genetic marker for Marker-aid breeding in pigeon.
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spelling pubmed-74771882020-09-08 Association of Dopamine D2 Receptor Gene Polymorphisms with Reproduction Traits in Domestic Pigeons (Columba livia) Yin, Zhaozheng Dong, Xinyang Ma, Youzhi Dong, Dingjuan J Poult Sci Full Papers Dopamine inhibited prolactin secretion via dopamine D2 receptor (DRD2) at the pituitary level, but its effects on reproduction in pigeons are unclear. In this study, Single Nucleotide Polymorphisms (SNPs) in the exons of DRD2 gene were identified and analyzed by using DNA sequencing methods in 60 female domestic pigeons (Columba livia), and the association between DRD2 polymorphisms and reproduction traits was also analyzed. Sequencing results showed that 7 nucleotide mutations were detected in the exon 1, 4, and 6 regions of DRD2 gene. The analysis revealed three genotypes (AA, AB, and BB) in exon 4 and two genotypes (AA, AB) in exon 6, in which the AA genotype was consistently dominant, and the A allele showed a dominant advantage. The C4532T genotypes located in exon 6 of DRD2 gene were significantly (P<0.05) associated with reproductive traits of pigeon. Moreover, the individuals with AB genotype had significantly higher fertility rate and total hatching number within 500 days of age than those with AA genotype (P<0.05). These findings suggested that the DRD2 gene should be included in future genetic studies of pigeon reproduction and the SNP of C4532T might be a potential candidate genetic marker for Marker-aid breeding in pigeon. Japan Poultry Science Association 2017-01-25 /pmc/articles/PMC7477188/ /pubmed/32908403 http://dx.doi.org/10.2141/jpsa.0160037 Text en 2017, Japan Poultry Science Association. The Journal of Poultry Science is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Full Papers
Yin, Zhaozheng
Dong, Xinyang
Ma, Youzhi
Dong, Dingjuan
Association of Dopamine D2 Receptor Gene Polymorphisms with Reproduction Traits in Domestic Pigeons (Columba livia)
title Association of Dopamine D2 Receptor Gene Polymorphisms with Reproduction Traits in Domestic Pigeons (Columba livia)
title_full Association of Dopamine D2 Receptor Gene Polymorphisms with Reproduction Traits in Domestic Pigeons (Columba livia)
title_fullStr Association of Dopamine D2 Receptor Gene Polymorphisms with Reproduction Traits in Domestic Pigeons (Columba livia)
title_full_unstemmed Association of Dopamine D2 Receptor Gene Polymorphisms with Reproduction Traits in Domestic Pigeons (Columba livia)
title_short Association of Dopamine D2 Receptor Gene Polymorphisms with Reproduction Traits in Domestic Pigeons (Columba livia)
title_sort association of dopamine d2 receptor gene polymorphisms with reproduction traits in domestic pigeons (columba livia)
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477188/
https://www.ncbi.nlm.nih.gov/pubmed/32908403
http://dx.doi.org/10.2141/jpsa.0160037
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