A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) consists of (1 → 6)-2-acetamido-2-deoxy-α-D-mannopyranosyl phosphate repeating units, O-acetylated at position C3 or C4. Glycomimetics appear attractive to overcome the CPS intrinsic lability in physiological media, due to cleavag...

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Detalles Bibliográficos
Autores principales: Enotarpi, Jacopo, Tontini, Marta, Balocchi, Cristiana, van der Es, Daan, Auberger, Ludovic, Balducci, Evita, Carboni, Filippo, Proietti, Daniela, Casini, Daniele, Filippov, Dmitri V., Overkleeft, Hermen S., van der Marel, Gijsbert A., Colombo, Cinzia, Romano, Maria Rosaria, Berti, Francesco, Costantino, Paolo, Codeé, Jeroen D. C., Lay, Luigi, Adamo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477203/
https://www.ncbi.nlm.nih.gov/pubmed/32895393
http://dx.doi.org/10.1038/s41467-020-18279-x

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