Torin2 inhibits the EGFR-TKI resistant Non-Small Lung Cancer cell proliferation through negative feedback regulation of Akt/mTOR signaling

It is known that mammalian target of rapamycin (mTOR) signaling plays an important role in NSCLC cells proliferation. Torin2 is a second-generation ATP-competitive inhibitor which is selective for mTOR activity. In this study, we investigated whether torin2 was effective against lung cancer cells, e...

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Detalles Bibliográficos
Autores principales: Hu, Yi, Zhang, Ji, Liu, Qun, Ke, Mingyao, Li, Jiurong, Suo, Wenhao, Guo, Weixi, Ma, Aiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477446/
https://www.ncbi.nlm.nih.gov/pubmed/32913468
http://dx.doi.org/10.7150/jca.37417

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