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ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer
N6-methyladenosine (m(6)A) messenger RNA methylation play important role in cell proliferation and tumorigenicity of endometrial cancer, but the key mechanism is not fully clear. Here, we found that RNA demethylase ALKBH5 expression was significantly upregulated in endometrial cancer, ALKBH5 was the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477457/ https://www.ncbi.nlm.nih.gov/pubmed/32913456 http://dx.doi.org/10.7150/jca.46097 |
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author | Pu, Xiaowen Gu, Zhuowei Gu, Zhengrong |
author_facet | Pu, Xiaowen Gu, Zhuowei Gu, Zhengrong |
author_sort | Pu, Xiaowen |
collection | PubMed |
description | N6-methyladenosine (m(6)A) messenger RNA methylation play important role in cell proliferation and tumorigenicity of endometrial cancer, but the key mechanism is not fully clear. Here, we found that RNA demethylase ALKBH5 expression was significantly upregulated in endometrial cancer, ALKBH5 was then identified to positively regulate proliferation and invasion of endometrial cancer. Mechanistically, the m(6)A eraser ALKBH5 demethylated target transcripts IGF1R and enhanced IGF1R mRNA stability, consequently promoting IGF1R translation and activating IGF1R signaling pathway. Thus, we demonstrated that ALKBH5 promoted proliferation and invasion of endometrial cancer via erasing IGF1R m(6)A-modifications, which suggests a potential therapeutic target for endometrial cancer. |
format | Online Article Text |
id | pubmed-7477457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-74774572020-09-09 ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer Pu, Xiaowen Gu, Zhuowei Gu, Zhengrong J Cancer Research Paper N6-methyladenosine (m(6)A) messenger RNA methylation play important role in cell proliferation and tumorigenicity of endometrial cancer, but the key mechanism is not fully clear. Here, we found that RNA demethylase ALKBH5 expression was significantly upregulated in endometrial cancer, ALKBH5 was then identified to positively regulate proliferation and invasion of endometrial cancer. Mechanistically, the m(6)A eraser ALKBH5 demethylated target transcripts IGF1R and enhanced IGF1R mRNA stability, consequently promoting IGF1R translation and activating IGF1R signaling pathway. Thus, we demonstrated that ALKBH5 promoted proliferation and invasion of endometrial cancer via erasing IGF1R m(6)A-modifications, which suggests a potential therapeutic target for endometrial cancer. Ivyspring International Publisher 2020-07-25 /pmc/articles/PMC7477457/ /pubmed/32913456 http://dx.doi.org/10.7150/jca.46097 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Pu, Xiaowen Gu, Zhuowei Gu, Zhengrong ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer |
title | ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer |
title_full | ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer |
title_fullStr | ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer |
title_full_unstemmed | ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer |
title_short | ALKBH5 regulates IGF1R expression to promote the Proliferation and Tumorigenicity of Endometrial Cancer |
title_sort | alkbh5 regulates igf1r expression to promote the proliferation and tumorigenicity of endometrial cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477457/ https://www.ncbi.nlm.nih.gov/pubmed/32913456 http://dx.doi.org/10.7150/jca.46097 |
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