Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing

Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis. Here, we report a microwave-excited antiba...

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Autores principales: Qiao, Yuqian, Liu, Xiangmei, Li, Bo, Han, Yong, Zheng, Yufeng, Yeung, Kelvin Wai Kwok, Li, Changyi, Cui, Zhenduo, Liang, Yanqin, Li, Zhaoyang, Zhu, Shengli, Wang, Xianbao, Wu, Shuilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477539/
https://www.ncbi.nlm.nih.gov/pubmed/32895387
http://dx.doi.org/10.1038/s41467-020-18268-0
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author Qiao, Yuqian
Liu, Xiangmei
Li, Bo
Han, Yong
Zheng, Yufeng
Yeung, Kelvin Wai Kwok
Li, Changyi
Cui, Zhenduo
Liang, Yanqin
Li, Zhaoyang
Zhu, Shengli
Wang, Xianbao
Wu, Shuilin
author_facet Qiao, Yuqian
Liu, Xiangmei
Li, Bo
Han, Yong
Zheng, Yufeng
Yeung, Kelvin Wai Kwok
Li, Changyi
Cui, Zhenduo
Liang, Yanqin
Li, Zhaoyang
Zhu, Shengli
Wang, Xianbao
Wu, Shuilin
author_sort Qiao, Yuqian
collection PubMed
description Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis. Here, we report a microwave-excited antibacterial nanocapturer system for treating deep tissue infections that consists of microwave-responsive Fe(3)O(4)/CNT and the chemotherapy agent gentamicin (Gent). This system, Fe(3)O(4)/CNT/Gent, is proven to efficiently target and eradicate MRSA-infected rabbit tibia osteomyelitis. Its robust antibacterial effectiveness is attributed to the precise bacteria-capturing ability and magnetic targeting of the nanocapturer, as well as the subsequent synergistic effects of precise microwaveocaloric therapy from Fe(3)O(4)/CNT and chemotherapy from the effective release of antibiotics in infection sites. The advanced target-nanocapturer of microwave-excited microwaveocaloric-chemotherapy with effective targeting developed in this study makes a major step forward in microwave therapy for deep tissue infections.
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spelling pubmed-74775392020-09-21 Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing Qiao, Yuqian Liu, Xiangmei Li, Bo Han, Yong Zheng, Yufeng Yeung, Kelvin Wai Kwok Li, Changyi Cui, Zhenduo Liang, Yanqin Li, Zhaoyang Zhu, Shengli Wang, Xianbao Wu, Shuilin Nat Commun Article Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis. Here, we report a microwave-excited antibacterial nanocapturer system for treating deep tissue infections that consists of microwave-responsive Fe(3)O(4)/CNT and the chemotherapy agent gentamicin (Gent). This system, Fe(3)O(4)/CNT/Gent, is proven to efficiently target and eradicate MRSA-infected rabbit tibia osteomyelitis. Its robust antibacterial effectiveness is attributed to the precise bacteria-capturing ability and magnetic targeting of the nanocapturer, as well as the subsequent synergistic effects of precise microwaveocaloric therapy from Fe(3)O(4)/CNT and chemotherapy from the effective release of antibiotics in infection sites. The advanced target-nanocapturer of microwave-excited microwaveocaloric-chemotherapy with effective targeting developed in this study makes a major step forward in microwave therapy for deep tissue infections. Nature Publishing Group UK 2020-09-07 /pmc/articles/PMC7477539/ /pubmed/32895387 http://dx.doi.org/10.1038/s41467-020-18268-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Qiao, Yuqian
Liu, Xiangmei
Li, Bo
Han, Yong
Zheng, Yufeng
Yeung, Kelvin Wai Kwok
Li, Changyi
Cui, Zhenduo
Liang, Yanqin
Li, Zhaoyang
Zhu, Shengli
Wang, Xianbao
Wu, Shuilin
Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing
title Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing
title_full Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing
title_fullStr Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing
title_full_unstemmed Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing
title_short Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing
title_sort treatment of mrsa-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477539/
https://www.ncbi.nlm.nih.gov/pubmed/32895387
http://dx.doi.org/10.1038/s41467-020-18268-0
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