Altering MYC phosphorylation in the epidermis increases the stem cell population and contributes to the development, progression, and metastasis of squamous cell carcinoma

cMYC (MYC) is a potent oncoprotein that is subject to post-translational modifications that affect its stability and activity. Here, we show that Serine 62 phosphorylation, which increases MYC stability and oncogenic activity, is elevated while Threonine 58 phosphorylation, which targets MYC for deg...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoyan, Langer, Ellen M., Daniel, Colin J., Janghorban, Mahnaz, Wu, Vivian, Wang, Xiao-Jing, Sears, Rosalie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477541/
https://www.ncbi.nlm.nih.gov/pubmed/32895364
http://dx.doi.org/10.1038/s41389-020-00261-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477541/
https://www.ncbi.nlm.nih.gov/pubmed/32895364
http://dx.doi.org/10.1038/s41389-020-00261-3

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