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Prediction of an MMP-1 inhibitor activity cliff using the SAR matrix approach and its experimental validation
A matrix metalloproteinase 1 (MMP-1) inhibitor activity cliff was predicted using the SAR Matrix method. Compound 4 was predicted as a highly potent activity cliff partner and found to possess 60 times higher inhibitory activity against MMP-1 than the structurally related compound 3. Furthermore, ph...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477548/ https://www.ncbi.nlm.nih.gov/pubmed/32895466 http://dx.doi.org/10.1038/s41598-020-71696-2 |