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Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia

Loss-of-function TET2 mutations (TET2(MT)) are common in myeloid neoplasia. TET2, a DNA dioxygenase, requires 2-oxoglutarate and Fe(II) to oxidize 5-methylcytosine. TET2(MT) thus result in hypermethylation and transcriptional repression. Ascorbic acid (AA) increases dioxygenase activity by facilitat...

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Detalles Bibliográficos
Autores principales:	Guan, Yihong, Greenberg, Edward F., Hasipek, Metis, Chen, Shi, Liu, Xiaochen, Kerr, Cassandra M., Gackowski, Daniel, Zarakowska, Ewelina, Radivoyevitch, Tomas, Gu, Xiaorong, Willard, Belinda, Visconte, Valeria, Makishima, Hideki, Nazha, Aziz, Mukherji, Mridul, Sekeres, Mikkael A., Saunthararajah, Yogen, Oliński, Ryszard, Xu, Mingjiang, Maciejewski, Jaroslaw P., Jha, Babal K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477582/ https://www.ncbi.nlm.nih.gov/pubmed/32895473 http://dx.doi.org/10.1038/s42003-020-01220-9

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