Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine

Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for regenerative medicine because of their strong immunosuppressive and regenerative abilities. The therapeutic effects of MSCs are based in part on their secretion of biologically active factors in extracellular vesicles...

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Detalles Bibliográficos
Autores principales: Ma, Zhan-Jun, Yang, Jing-Jing, Lu, Yu-Bao, Liu, Zhao-Yang, Wang, Xue-Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477653/
https://www.ncbi.nlm.nih.gov/pubmed/32952861
http://dx.doi.org/10.4252/wjsc.v12.i8.814
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author Ma, Zhan-Jun
Yang, Jing-Jing
Lu, Yu-Bao
Liu, Zhao-Yang
Wang, Xue-Xi
author_facet Ma, Zhan-Jun
Yang, Jing-Jing
Lu, Yu-Bao
Liu, Zhao-Yang
Wang, Xue-Xi
author_sort Ma, Zhan-Jun
collection PubMed
description Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for regenerative medicine because of their strong immunosuppressive and regenerative abilities. The therapeutic effects of MSCs are based in part on their secretion of biologically active factors in extracellular vesicles known as exosomes. Exosomes have a diameter of 30-100 nm and mediate intercellular communication and material exchange. MSC-derived exosomes (MSC-Exos) have potential for cell-free therapy for diseases of, for instance, the kidney, liver, heart, nervous system, and musculoskeletal system. Hence, MSC-Exos are an alternative to MSC-based therapy for regenerative medicine. We review MSC-Exos and their therapeutic potential for a variety of diseases and injuries.
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spelling pubmed-74776532020-09-18 Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine Ma, Zhan-Jun Yang, Jing-Jing Lu, Yu-Bao Liu, Zhao-Yang Wang, Xue-Xi World J Stem Cells Review Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for regenerative medicine because of their strong immunosuppressive and regenerative abilities. The therapeutic effects of MSCs are based in part on their secretion of biologically active factors in extracellular vesicles known as exosomes. Exosomes have a diameter of 30-100 nm and mediate intercellular communication and material exchange. MSC-derived exosomes (MSC-Exos) have potential for cell-free therapy for diseases of, for instance, the kidney, liver, heart, nervous system, and musculoskeletal system. Hence, MSC-Exos are an alternative to MSC-based therapy for regenerative medicine. We review MSC-Exos and their therapeutic potential for a variety of diseases and injuries. Baishideng Publishing Group Inc 2020-08-26 2020-08-26 /pmc/articles/PMC7477653/ /pubmed/32952861 http://dx.doi.org/10.4252/wjsc.v12.i8.814 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Ma, Zhan-Jun
Yang, Jing-Jing
Lu, Yu-Bao
Liu, Zhao-Yang
Wang, Xue-Xi
Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine
title Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine
title_full Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine
title_fullStr Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine
title_full_unstemmed Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine
title_short Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine
title_sort mesenchymal stem cell-derived exosomes: toward cell-free therapeutic strategies in regenerative medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477653/
https://www.ncbi.nlm.nih.gov/pubmed/32952861
http://dx.doi.org/10.4252/wjsc.v12.i8.814
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