Practicalities in running early-phase trials using the time-to-event continual reassessment method (TiTE-CRM) for interventions with long toxicity periods using two radiotherapy oncology trials as examples

BACKGROUND: Awareness of model-based designs for dose-finding studies such as the Continual Reassessment Method (CRM) is now becoming more commonplace amongst clinicians, statisticians and trial management staff. In some settings toxicities can occur a long time after treatment has finished, resulti...

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Detalles Bibliográficos
Autores principales: van Werkhoven, Erik, Hinsley, Samantha, Frangou, Eleni, Holmes, Jane, de Haan, Rosemarie, Hawkins, Maria, Brown, Sarah, Love, Sharon B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477911/
https://www.ncbi.nlm.nih.gov/pubmed/32571298
http://dx.doi.org/10.1186/s12874-020-01012-z

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