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Hypothesis of COVID-19 Therapy with Sildenafil
BACKGOUND: Bacterial or viral infections often cause acute and severe systemic inflammation, which affects the lungs lipopolysaccharide (LPS), a pathogenic component of the membrane of gram-negative bacteria, stimulates active innate immune cells, monocytes, macrophages to produce inducible nitric o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478270/ https://www.ncbi.nlm.nih.gov/pubmed/32939238 http://dx.doi.org/10.4103/ijpvm.IJPVM_258_20 |
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author | Mario, Limodio Roberto, Menicagli Marta, Limodio Teresa, Casotti Maria Laura, Menicagli |
author_facet | Mario, Limodio Roberto, Menicagli Marta, Limodio Teresa, Casotti Maria Laura, Menicagli |
author_sort | Mario, Limodio |
collection | PubMed |
description | BACKGOUND: Bacterial or viral infections often cause acute and severe systemic inflammation, which affects the lungs lipopolysaccharide (LPS), a pathogenic component of the membrane of gram-negative bacteria, stimulates active innate immune cells, monocytes, macrophages to produce inducible nitric oxide synthase (iNOS). Excess production of this compound occurs in COVID-19 resulting in inflammatory cascade and thromboembolism. We intend to propose the use of sildenafil to reduce this production. METHOD: The analysis of biochemical pathways shows that viral infection produces a high amount of nitric oxide (NO), with an acute inflammatory process. RESULTS: In the case of COVID-19 infection we verified that numerous biochemical processes activate a cascade of inflammatory processes through the activation of iNOS with uncontrolled generation of (NO). CONCLUSIONS: iNOS is the cause of damage to host cells with a consequent pulmonary thromboembolic lung phenomenon in a contest of interstitial pneumonia. This study proposes the use of sildenafil to counter the inflammatory cascade and thromboembolic episodes. |
format | Online Article Text |
id | pubmed-7478270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-74782702020-09-15 Hypothesis of COVID-19 Therapy with Sildenafil Mario, Limodio Roberto, Menicagli Marta, Limodio Teresa, Casotti Maria Laura, Menicagli Int J Prev Med Brief Communication BACKGOUND: Bacterial or viral infections often cause acute and severe systemic inflammation, which affects the lungs lipopolysaccharide (LPS), a pathogenic component of the membrane of gram-negative bacteria, stimulates active innate immune cells, monocytes, macrophages to produce inducible nitric oxide synthase (iNOS). Excess production of this compound occurs in COVID-19 resulting in inflammatory cascade and thromboembolism. We intend to propose the use of sildenafil to reduce this production. METHOD: The analysis of biochemical pathways shows that viral infection produces a high amount of nitric oxide (NO), with an acute inflammatory process. RESULTS: In the case of COVID-19 infection we verified that numerous biochemical processes activate a cascade of inflammatory processes through the activation of iNOS with uncontrolled generation of (NO). CONCLUSIONS: iNOS is the cause of damage to host cells with a consequent pulmonary thromboembolic lung phenomenon in a contest of interstitial pneumonia. This study proposes the use of sildenafil to counter the inflammatory cascade and thromboembolic episodes. Wolters Kluwer - Medknow 2020-06-26 /pmc/articles/PMC7478270/ /pubmed/32939238 http://dx.doi.org/10.4103/ijpvm.IJPVM_258_20 Text en Copyright: © 2020 International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Brief Communication Mario, Limodio Roberto, Menicagli Marta, Limodio Teresa, Casotti Maria Laura, Menicagli Hypothesis of COVID-19 Therapy with Sildenafil |
title | Hypothesis of COVID-19 Therapy with Sildenafil |
title_full | Hypothesis of COVID-19 Therapy with Sildenafil |
title_fullStr | Hypothesis of COVID-19 Therapy with Sildenafil |
title_full_unstemmed | Hypothesis of COVID-19 Therapy with Sildenafil |
title_short | Hypothesis of COVID-19 Therapy with Sildenafil |
title_sort | hypothesis of covid-19 therapy with sildenafil |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478270/ https://www.ncbi.nlm.nih.gov/pubmed/32939238 http://dx.doi.org/10.4103/ijpvm.IJPVM_258_20 |
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