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Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis

OBJECTIVE: Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near the melanocortin 4 receptor (MC4R), gene which are associated with risk of obesity. Since obesity is an established risk factor of cancer, several studies have examined the association between SNPs...

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Autores principales: Zeng, Tian, Zhao, Jing, Kang, Yu, Wang, Xiaojiao, Xie, Hongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478401/
https://www.ncbi.nlm.nih.gov/pubmed/32899047
http://dx.doi.org/10.1097/MD.0000000000022003
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author Zeng, Tian
Zhao, Jing
Kang, Yu
Wang, Xiaojiao
Xie, Hongjun
author_facet Zeng, Tian
Zhao, Jing
Kang, Yu
Wang, Xiaojiao
Xie, Hongjun
author_sort Zeng, Tian
collection PubMed
description OBJECTIVE: Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near the melanocortin 4 receptor (MC4R), gene which are associated with risk of obesity. Since obesity is an established risk factor of cancer, several studies have examined the association between SNPs near the MC4R gene and cancer risk, but the findings are inconsistent. The present study aimed to perform a meta-analysis to clarify the association between SNPs near MC4R and cancer risk. METHODS: The PubMed and Embase databases were searched for potentially eligible publications. All studies that evaluated the association between MC4R rs17782313 SNP (or its proxy rs12970134) and cancer risk were included. The pooled odds ratios with 95% confidence intervals (CIs) were calculated using the random-effects model. And subgroup analysis by cancer type (colorectal cancer, endometrial cancer and breast cancer) was conducted for further investigate the association. RESULTS: A total of 6 eligible studies (6517 cases and 16,886 controls) were included in the present meta-analysis. The results indicated that MC4R rs17782313 SNP was moderately associated with cancer risk (odds ratio = 1.12, 95% CI = 1.01–1.24). However, the subgroup analysis between different cancer types shows that rs17782313 is only associated with colorectal cancer but not the endometrial cancer and breast cancer. Risk factor in colorectal cancer was both significantly associated with rs17782313 with and without adjustment for body mass index; while the risk factor of the endometrial cancer and breast cancer were both not associated with the rs17782313 with and without adjustment for body mass index. There was no publication bias for the association between MC4R rs17782313 and cancer risk. CONCLUSION: The present meta-analysis confirmed the moderate association between MC4R rs17782313 and cancer risk.
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spelling pubmed-74784012020-09-16 Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis Zeng, Tian Zhao, Jing Kang, Yu Wang, Xiaojiao Xie, Hongjun Medicine (Baltimore) 5700 OBJECTIVE: Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near the melanocortin 4 receptor (MC4R), gene which are associated with risk of obesity. Since obesity is an established risk factor of cancer, several studies have examined the association between SNPs near the MC4R gene and cancer risk, but the findings are inconsistent. The present study aimed to perform a meta-analysis to clarify the association between SNPs near MC4R and cancer risk. METHODS: The PubMed and Embase databases were searched for potentially eligible publications. All studies that evaluated the association between MC4R rs17782313 SNP (or its proxy rs12970134) and cancer risk were included. The pooled odds ratios with 95% confidence intervals (CIs) were calculated using the random-effects model. And subgroup analysis by cancer type (colorectal cancer, endometrial cancer and breast cancer) was conducted for further investigate the association. RESULTS: A total of 6 eligible studies (6517 cases and 16,886 controls) were included in the present meta-analysis. The results indicated that MC4R rs17782313 SNP was moderately associated with cancer risk (odds ratio = 1.12, 95% CI = 1.01–1.24). However, the subgroup analysis between different cancer types shows that rs17782313 is only associated with colorectal cancer but not the endometrial cancer and breast cancer. Risk factor in colorectal cancer was both significantly associated with rs17782313 with and without adjustment for body mass index; while the risk factor of the endometrial cancer and breast cancer were both not associated with the rs17782313 with and without adjustment for body mass index. There was no publication bias for the association between MC4R rs17782313 and cancer risk. CONCLUSION: The present meta-analysis confirmed the moderate association between MC4R rs17782313 and cancer risk. Lippincott Williams & Wilkins 2020-09-04 /pmc/articles/PMC7478401/ /pubmed/32899047 http://dx.doi.org/10.1097/MD.0000000000022003 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5700
Zeng, Tian
Zhao, Jing
Kang, Yu
Wang, Xiaojiao
Xie, Hongjun
Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis
title Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis
title_full Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis
title_fullStr Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis
title_full_unstemmed Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis
title_short Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis
title_sort association between polymorphism near the mc4r gene and cancer risk: a meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478401/
https://www.ncbi.nlm.nih.gov/pubmed/32899047
http://dx.doi.org/10.1097/MD.0000000000022003
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