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Platelet activity with hemoglobin level in patients with hemodialysis: Prospective study

BACKGROUND: VerifyNow (VN; Accumetrics, San Diego, CA) P2Y12 reaction unit (PRU) has an inverse relation with hemoglobin level (Hb). Chronic kidney disease (CKD) is associated with low response to clopidogrel and low Hb. Our aim is to investigate the relation between PRU and Hb, and to assess whethe...

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Autores principales: Kim, Jae Min, Kim, Jin Sug, Kim, Hyung Oh, Lee, So Ra, Rhew, Jae Hwan, Woo, Jong Shin, Cho, Jang Hyun, Jeong, Kyung Hwan, Kim, Weon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478496/
https://www.ncbi.nlm.nih.gov/pubmed/32150071
http://dx.doi.org/10.1097/MD.0000000000019336
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author Kim, Jae Min
Kim, Jin Sug
Kim, Hyung Oh
Lee, So Ra
Rhew, Jae Hwan
Woo, Jong Shin
Cho, Jang Hyun
Jeong, Kyung Hwan
Kim, Weon
author_facet Kim, Jae Min
Kim, Jin Sug
Kim, Hyung Oh
Lee, So Ra
Rhew, Jae Hwan
Woo, Jong Shin
Cho, Jang Hyun
Jeong, Kyung Hwan
Kim, Weon
author_sort Kim, Jae Min
collection PubMed
description BACKGROUND: VerifyNow (VN; Accumetrics, San Diego, CA) P2Y12 reaction unit (PRU) has an inverse relation with hemoglobin level (Hb). Chronic kidney disease (CKD) is associated with low response to clopidogrel and low Hb. Our aim is to investigate the relation between PRU and Hb, and to assess whether Hb directly affects PRU or not in patients with CKD undergoing hemodialysis (HD). METHODS: We analyzed the relation between PRU and Hb in 43 HD patients and compared it with a control group of 127 patients with normal renal function. Both groups underwent percutaneous coronary intervention for stable coronary artery disease. We also compared PRU between the 2 groups considering Hb as a confounding factor. RESULTS: In the control group, Hb and PRU showed a significant inverse correlation (correlation coefficient r = −0.340; P < .001), but not in the HD group (correlation coefficient r = −0.099; P = .53). PRU was higher in the HD group than the control group after adjusting for the influence of Hb (299.2 [95% confidence interval: 278.4–316.7] vs 248.7 [95% confidence interval: 227.7–269.0]; P < .001), even after propensity score matching (299.2 [95% confidence interval: 278.4–316.7] vs 241.7 [95% confidence interval: 221.8–262.2]; P < .001). CONCLUSIONS: PRU was higher regardless of lower Hb in CKD on HD patients than normal renal function patients. Therefore, Hb was not crucial factor to decide PRU in CKD on HD patients in this study.
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spelling pubmed-74784962020-09-16 Platelet activity with hemoglobin level in patients with hemodialysis: Prospective study Kim, Jae Min Kim, Jin Sug Kim, Hyung Oh Lee, So Ra Rhew, Jae Hwan Woo, Jong Shin Cho, Jang Hyun Jeong, Kyung Hwan Kim, Weon Medicine (Baltimore) 3400 BACKGROUND: VerifyNow (VN; Accumetrics, San Diego, CA) P2Y12 reaction unit (PRU) has an inverse relation with hemoglobin level (Hb). Chronic kidney disease (CKD) is associated with low response to clopidogrel and low Hb. Our aim is to investigate the relation between PRU and Hb, and to assess whether Hb directly affects PRU or not in patients with CKD undergoing hemodialysis (HD). METHODS: We analyzed the relation between PRU and Hb in 43 HD patients and compared it with a control group of 127 patients with normal renal function. Both groups underwent percutaneous coronary intervention for stable coronary artery disease. We also compared PRU between the 2 groups considering Hb as a confounding factor. RESULTS: In the control group, Hb and PRU showed a significant inverse correlation (correlation coefficient r = −0.340; P < .001), but not in the HD group (correlation coefficient r = −0.099; P = .53). PRU was higher in the HD group than the control group after adjusting for the influence of Hb (299.2 [95% confidence interval: 278.4–316.7] vs 248.7 [95% confidence interval: 227.7–269.0]; P < .001), even after propensity score matching (299.2 [95% confidence interval: 278.4–316.7] vs 241.7 [95% confidence interval: 221.8–262.2]; P < .001). CONCLUSIONS: PRU was higher regardless of lower Hb in CKD on HD patients than normal renal function patients. Therefore, Hb was not crucial factor to decide PRU in CKD on HD patients in this study. Wolters Kluwer Health 2020-03-06 /pmc/articles/PMC7478496/ /pubmed/32150071 http://dx.doi.org/10.1097/MD.0000000000019336 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 3400
Kim, Jae Min
Kim, Jin Sug
Kim, Hyung Oh
Lee, So Ra
Rhew, Jae Hwan
Woo, Jong Shin
Cho, Jang Hyun
Jeong, Kyung Hwan
Kim, Weon
Platelet activity with hemoglobin level in patients with hemodialysis: Prospective study
title Platelet activity with hemoglobin level in patients with hemodialysis: Prospective study
title_full Platelet activity with hemoglobin level in patients with hemodialysis: Prospective study
title_fullStr Platelet activity with hemoglobin level in patients with hemodialysis: Prospective study
title_full_unstemmed Platelet activity with hemoglobin level in patients with hemodialysis: Prospective study
title_short Platelet activity with hemoglobin level in patients with hemodialysis: Prospective study
title_sort platelet activity with hemoglobin level in patients with hemodialysis: prospective study
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478496/
https://www.ncbi.nlm.nih.gov/pubmed/32150071
http://dx.doi.org/10.1097/MD.0000000000019336
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