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Hematological indices as indicators of silent inflammation in achalasia patients: A cross-sectional study

Complete blood count (CBC)-derived parameters such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), eosinophil-to-lymphocyte (ELR) ratio, and platelet-to-lymphocyte ratio (PLR) are sensitive markers of occult inflammation and disease activity for systemic lupus erythemato...

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Autores principales: López-Verdugo, Fidel, Furuzawa-Carballeda, Janette, Romero-Hernández, Fernanda, Coss-Adame, Enrique, Valdovinos, Miguel A., Priego-Ranero, Angel, Olvera-Prado, Héctor, Narváez-Chavez, Sofía, Peralta-Figueroa, José, Torres-Villalobos, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478540/
https://www.ncbi.nlm.nih.gov/pubmed/32118763
http://dx.doi.org/10.1097/MD.0000000000019326
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author López-Verdugo, Fidel
Furuzawa-Carballeda, Janette
Romero-Hernández, Fernanda
Coss-Adame, Enrique
Valdovinos, Miguel A.
Priego-Ranero, Angel
Olvera-Prado, Héctor
Narváez-Chavez, Sofía
Peralta-Figueroa, José
Torres-Villalobos, Gonzalo
author_facet López-Verdugo, Fidel
Furuzawa-Carballeda, Janette
Romero-Hernández, Fernanda
Coss-Adame, Enrique
Valdovinos, Miguel A.
Priego-Ranero, Angel
Olvera-Prado, Héctor
Narváez-Chavez, Sofía
Peralta-Figueroa, José
Torres-Villalobos, Gonzalo
author_sort López-Verdugo, Fidel
collection PubMed
description Complete blood count (CBC)-derived parameters such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), eosinophil-to-lymphocyte (ELR) ratio, and platelet-to-lymphocyte ratio (PLR) are sensitive markers of occult inflammation and disease activity for systemic lupus erythematosus, rheumatoid arthritis, psoriasis, esophageal cancer, etc. We assessed NLR, PLR, MLR, and ELR as indicators of inflammation in achalasia patients. This cross-sectional study included 103 achalasia patients and 500 healthy blood donor volunteers (HD). Demographic, clinical and laboratory information was collected. NLR, MLR, ELR and PLR were calculated. Peripheral Th22, Th17, Th2 and Th1 subsets were determined by flow cytometry. Correlation between hematologic indices and clinical questionnaires scores, HRM parameters and CD4+ T-cells were assessed. Hematologic parameters associated with the different achalasia subtypes were evaluated by logistic regression analysis. Hemoglobin, leukocytes, lymphocytes, monocytes, and platelets counts were significantly lower in achalasia patients vs controls. NLR (P = .006) and ELR (P < .05) were higher in achalasia patients vs controls. NLR was significantly associated with achalasia in multivariate analysis (P < .001). Compared to HD, the achalasia group was 1.804 times more likely to have higher NLR (95% CI 1.287–2.59; P < .001). GERD-HRQL score had statistically significant correlations with PLR (Pearson's rho:0.318, P = .003), and ELR (Pearson's rho:0.216; P = .044). No correlation between CD4+ T-cells and hematologic indices were determined. NLR with a cut-off value of ≥2.20 and area under the curve of 0.581 yielded a specificity of 80% and sensitivity of 40%, for the diagnosis of achalasia. NLR is increased in achalasia patients vs HD. Sensitivity and specificity achieved by NLR may contribute to a clinical and manometric evaluation. We suggest these indices as potential indicators of silent inflammation and disease activity.
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spelling pubmed-74785402020-09-16 Hematological indices as indicators of silent inflammation in achalasia patients: A cross-sectional study López-Verdugo, Fidel Furuzawa-Carballeda, Janette Romero-Hernández, Fernanda Coss-Adame, Enrique Valdovinos, Miguel A. Priego-Ranero, Angel Olvera-Prado, Héctor Narváez-Chavez, Sofía Peralta-Figueroa, José Torres-Villalobos, Gonzalo Medicine (Baltimore) 4500 Complete blood count (CBC)-derived parameters such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), eosinophil-to-lymphocyte (ELR) ratio, and platelet-to-lymphocyte ratio (PLR) are sensitive markers of occult inflammation and disease activity for systemic lupus erythematosus, rheumatoid arthritis, psoriasis, esophageal cancer, etc. We assessed NLR, PLR, MLR, and ELR as indicators of inflammation in achalasia patients. This cross-sectional study included 103 achalasia patients and 500 healthy blood donor volunteers (HD). Demographic, clinical and laboratory information was collected. NLR, MLR, ELR and PLR were calculated. Peripheral Th22, Th17, Th2 and Th1 subsets were determined by flow cytometry. Correlation between hematologic indices and clinical questionnaires scores, HRM parameters and CD4+ T-cells were assessed. Hematologic parameters associated with the different achalasia subtypes were evaluated by logistic regression analysis. Hemoglobin, leukocytes, lymphocytes, monocytes, and platelets counts were significantly lower in achalasia patients vs controls. NLR (P = .006) and ELR (P < .05) were higher in achalasia patients vs controls. NLR was significantly associated with achalasia in multivariate analysis (P < .001). Compared to HD, the achalasia group was 1.804 times more likely to have higher NLR (95% CI 1.287–2.59; P < .001). GERD-HRQL score had statistically significant correlations with PLR (Pearson's rho:0.318, P = .003), and ELR (Pearson's rho:0.216; P = .044). No correlation between CD4+ T-cells and hematologic indices were determined. NLR with a cut-off value of ≥2.20 and area under the curve of 0.581 yielded a specificity of 80% and sensitivity of 40%, for the diagnosis of achalasia. NLR is increased in achalasia patients vs HD. Sensitivity and specificity achieved by NLR may contribute to a clinical and manometric evaluation. We suggest these indices as potential indicators of silent inflammation and disease activity. Wolters Kluwer Health 2020-02-28 /pmc/articles/PMC7478540/ /pubmed/32118763 http://dx.doi.org/10.1097/MD.0000000000019326 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4500
López-Verdugo, Fidel
Furuzawa-Carballeda, Janette
Romero-Hernández, Fernanda
Coss-Adame, Enrique
Valdovinos, Miguel A.
Priego-Ranero, Angel
Olvera-Prado, Héctor
Narváez-Chavez, Sofía
Peralta-Figueroa, José
Torres-Villalobos, Gonzalo
Hematological indices as indicators of silent inflammation in achalasia patients: A cross-sectional study
title Hematological indices as indicators of silent inflammation in achalasia patients: A cross-sectional study
title_full Hematological indices as indicators of silent inflammation in achalasia patients: A cross-sectional study
title_fullStr Hematological indices as indicators of silent inflammation in achalasia patients: A cross-sectional study
title_full_unstemmed Hematological indices as indicators of silent inflammation in achalasia patients: A cross-sectional study
title_short Hematological indices as indicators of silent inflammation in achalasia patients: A cross-sectional study
title_sort hematological indices as indicators of silent inflammation in achalasia patients: a cross-sectional study
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478540/
https://www.ncbi.nlm.nih.gov/pubmed/32118763
http://dx.doi.org/10.1097/MD.0000000000019326
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