Dronedarone-Mediated Acute Hepatic and Renal Toxicity

Dronedarone, a drug similar in chemical properties to amiodarone, was designed to have similar pharmacodynamic properties as amiodarone with fewer side effects. Although there have been cases of chronic liver enzyme elevation with dronedarone, only a few cases have been reported in literature where...

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Detalles Bibliográficos
Autores principales: Khan, Zarak H, Mukhtar, Kashif, Ahmed, Munis M, Zaidi, Syeda Ramsha, Abd Algayoum, Randa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Gastroenterology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478565/
https://www.ncbi.nlm.nih.gov/pubmed/32923213
http://dx.doi.org/10.7759/cureus.9611
Descripción
Sumario:Dronedarone, a drug similar in chemical properties to amiodarone, was designed to have similar pharmacodynamic properties as amiodarone with fewer side effects. Although there have been cases of chronic liver enzyme elevation with dronedarone, only a few cases have been reported in literature where it has led to rapid onset of liver failure. We present the case of an 86-year-old male who developed acute liver failure concomitantly with acute kidney failure after he was started on dronedarone therapy.

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