Dronedarone-Mediated Acute Hepatic and Renal Toxicity

Dronedarone, a drug similar in chemical properties to amiodarone, was designed to have similar pharmacodynamic properties as amiodarone with fewer side effects. Although there have been cases of chronic liver enzyme elevation with dronedarone, only a few cases have been reported in literature where...

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Autores principales: Khan, Zarak H, Mukhtar, Kashif, Ahmed, Munis M, Zaidi, Syeda Ramsha, Abd Algayoum, Randa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Gastroenterology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478565/
https://www.ncbi.nlm.nih.gov/pubmed/32923213
http://dx.doi.org/10.7759/cureus.9611
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author Khan, Zarak H
Mukhtar, Kashif
Ahmed, Munis M
Zaidi, Syeda Ramsha
Abd Algayoum, Randa
author_facet Khan, Zarak H
Mukhtar, Kashif
Ahmed, Munis M
Zaidi, Syeda Ramsha
Abd Algayoum, Randa
author_sort Khan, Zarak H
collection PubMed
description Dronedarone, a drug similar in chemical properties to amiodarone, was designed to have similar pharmacodynamic properties as amiodarone with fewer side effects. Although there have been cases of chronic liver enzyme elevation with dronedarone, only a few cases have been reported in literature where it has led to rapid onset of liver failure. We present the case of an 86-year-old male who developed acute liver failure concomitantly with acute kidney failure after he was started on dronedarone therapy.
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spelling pubmed-74785652020-09-11 Dronedarone-Mediated Acute Hepatic and Renal Toxicity Khan, Zarak H Mukhtar, Kashif Ahmed, Munis M Zaidi, Syeda Ramsha Abd Algayoum, Randa Cureus Gastroenterology Dronedarone, a drug similar in chemical properties to amiodarone, was designed to have similar pharmacodynamic properties as amiodarone with fewer side effects. Although there have been cases of chronic liver enzyme elevation with dronedarone, only a few cases have been reported in literature where it has led to rapid onset of liver failure. We present the case of an 86-year-old male who developed acute liver failure concomitantly with acute kidney failure after he was started on dronedarone therapy. Cureus 2020-08-07 /pmc/articles/PMC7478565/ /pubmed/32923213 http://dx.doi.org/10.7759/cureus.9611 Text en Copyright © 2020, Khan et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Gastroenterology
Khan, Zarak H
Mukhtar, Kashif
Ahmed, Munis M
Zaidi, Syeda Ramsha
Abd Algayoum, Randa
Dronedarone-Mediated Acute Hepatic and Renal Toxicity
title Dronedarone-Mediated Acute Hepatic and Renal Toxicity
title_full Dronedarone-Mediated Acute Hepatic and Renal Toxicity
title_fullStr Dronedarone-Mediated Acute Hepatic and Renal Toxicity
title_full_unstemmed Dronedarone-Mediated Acute Hepatic and Renal Toxicity
title_short Dronedarone-Mediated Acute Hepatic and Renal Toxicity
title_sort dronedarone-mediated acute hepatic and renal toxicity
topic Gastroenterology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478565/
https://www.ncbi.nlm.nih.gov/pubmed/32923213
http://dx.doi.org/10.7759/cureus.9611
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AT zaidisyedaramsha dronedaronemediatedacutehepaticandrenaltoxicity
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