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Clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock
Sepsis can cause septic shock, multiple organ dysfunction and even death. The combination of different blood purification would be the certain trend in the treatment of sepsis. This study was to evaluate the clinical effects of hemoperfusion (HP) combined with pulse high volume hemofiltration (PHVHF...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478611/ https://www.ncbi.nlm.nih.gov/pubmed/32118713 http://dx.doi.org/10.1097/MD.0000000000019058 |
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author | Chu, Laping Li, Guangyao Yu, Yafen Bao, Xiaoyan Wei, Hongyi Hu, Minhong |
author_facet | Chu, Laping Li, Guangyao Yu, Yafen Bao, Xiaoyan Wei, Hongyi Hu, Minhong |
author_sort | Chu, Laping |
collection | PubMed |
description | Sepsis can cause septic shock, multiple organ dysfunction and even death. The combination of different blood purification would be the certain trend in the treatment of sepsis. This study was to evaluate the clinical effects of hemoperfusion (HP) combined with pulse high volume hemofiltration (PHVHF) on septic shock. Thirty cases were involved in this study and were randomly divided into two groups: HP and PHVHF group (n = 15) and CVVH (continuous veno-venous hemofiltration) group (n = 15). Acute physiology and chronic health evaluation (APACHE) II scores, sequential organ failure assessment (SOFA) scores as well as biochemical changes were measured before and after the treatment. The levels of IL-6, IL-10, and TNF-α in plasma were assessed by ELISA before and after treatment for 2 and 24 h. The norepinephrine doses were also analyzed. The 28-day mortalities in both groups were also compared. In both groups, body temperature (BT), respiratory rate (RR), white blood cells (WBC), C-reactive protein (CRP), Procalcitonin (PCT), lactic acid, serum creatinine, APACHE II scores and SOFA scores decreased after hemofiltration (P < .05). The HP&PHVHF group was superior to the CVVH group in CRP, APACHE II score (P < .01), and heart rate (HR), WBC, PCT, SOFA (P < .05). The doses of norepinephrine were also decreased after treatment (P < .01), with more reduction in the HP&PHVHF group (P < .05). After 24 h of treatment, the levels of IL-6, IL-10, and TNF-α decreased in both groups (P < .05), and the decrease was more significant in HP&PHVHF group (P < .05). In combined group, after 2 h of hemoperfison, there was a significant reduction in these inflammatory factors (P < .01). Combined therapy group's mortality was 26.7%, while CVVH group's was 40%. HP combined with PHVHF has a significant effect on septic shock and can be an important therapy for septic shock. |
format | Online Article Text |
id | pubmed-7478611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-74786112020-09-24 Clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock Chu, Laping Li, Guangyao Yu, Yafen Bao, Xiaoyan Wei, Hongyi Hu, Minhong Medicine (Baltimore) 5200 Sepsis can cause septic shock, multiple organ dysfunction and even death. The combination of different blood purification would be the certain trend in the treatment of sepsis. This study was to evaluate the clinical effects of hemoperfusion (HP) combined with pulse high volume hemofiltration (PHVHF) on septic shock. Thirty cases were involved in this study and were randomly divided into two groups: HP and PHVHF group (n = 15) and CVVH (continuous veno-venous hemofiltration) group (n = 15). Acute physiology and chronic health evaluation (APACHE) II scores, sequential organ failure assessment (SOFA) scores as well as biochemical changes were measured before and after the treatment. The levels of IL-6, IL-10, and TNF-α in plasma were assessed by ELISA before and after treatment for 2 and 24 h. The norepinephrine doses were also analyzed. The 28-day mortalities in both groups were also compared. In both groups, body temperature (BT), respiratory rate (RR), white blood cells (WBC), C-reactive protein (CRP), Procalcitonin (PCT), lactic acid, serum creatinine, APACHE II scores and SOFA scores decreased after hemofiltration (P < .05). The HP&PHVHF group was superior to the CVVH group in CRP, APACHE II score (P < .01), and heart rate (HR), WBC, PCT, SOFA (P < .05). The doses of norepinephrine were also decreased after treatment (P < .01), with more reduction in the HP&PHVHF group (P < .05). After 24 h of treatment, the levels of IL-6, IL-10, and TNF-α decreased in both groups (P < .05), and the decrease was more significant in HP&PHVHF group (P < .05). In combined group, after 2 h of hemoperfison, there was a significant reduction in these inflammatory factors (P < .01). Combined therapy group's mortality was 26.7%, while CVVH group's was 40%. HP combined with PHVHF has a significant effect on septic shock and can be an important therapy for septic shock. Wolters Kluwer Health 2020-02-28 /pmc/articles/PMC7478611/ /pubmed/32118713 http://dx.doi.org/10.1097/MD.0000000000019058 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5200 Chu, Laping Li, Guangyao Yu, Yafen Bao, Xiaoyan Wei, Hongyi Hu, Minhong Clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock |
title | Clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock |
title_full | Clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock |
title_fullStr | Clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock |
title_full_unstemmed | Clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock |
title_short | Clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock |
title_sort | clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock |
topic | 5200 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478611/ https://www.ncbi.nlm.nih.gov/pubmed/32118713 http://dx.doi.org/10.1097/MD.0000000000019058 |
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