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Underweight increases the risk of primary open-angle glaucoma in diabetes patients: A Korean nationwide cohort study
The impact of underweight on the risk of developing primary open-angle glaucoma (POAG) is not known, although the association between obesity and POAG has been well studied. We evaluated the risk of POAG among underweight patients by studying a nationwide cohort sample in South Korea. We analyzed da...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478655/ https://www.ncbi.nlm.nih.gov/pubmed/32150063 http://dx.doi.org/10.1097/MD.0000000000019285 |
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author | Na, Kyung-Sun Kim, Jin-Ho Paik, Ji-Sun Cho, Won-Kyung Ha, Minji Park, Yong-Gyu Yang, Suk-Woo |
author_facet | Na, Kyung-Sun Kim, Jin-Ho Paik, Ji-Sun Cho, Won-Kyung Ha, Minji Park, Yong-Gyu Yang, Suk-Woo |
author_sort | Na, Kyung-Sun |
collection | PubMed |
description | The impact of underweight on the risk of developing primary open-angle glaucoma (POAG) is not known, although the association between obesity and POAG has been well studied. We evaluated the risk of POAG among underweight patients by studying a nationwide cohort sample in South Korea. We analyzed data from the Korean National Health Insurance Research Database collected between 2009 and 2012 for 17,000,636 patients aged 40 years or older. Newly diagnosed POAG in the cohort was identified using claims data between 2009 and 2015. A total of 442,829 individuals (2.60%) were classified as underweight (body mass index [BMI] < 18.5 kg/m(2)). During the follow-up period, 435,756 (2.56%) subjects were newly diagnosed with POAG. Multivariate analyses revealed that underweight was significantly related to an increased risk of future POAG development, by 9.8% and 27.8% in individuals with and without diabetes, respectively. There was a reverse J-shaped relationship between BMI and risk of POAG in the normal, impaired glucose tolerance, and diabetes groups; especially, this relationship was most notable in participants with diabetes. Patients who were underweight exhibited a significantly higher prospective risk of POAG, even after adjusting for confounding factors. |
format | Online Article Text |
id | pubmed-7478655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-74786552020-09-24 Underweight increases the risk of primary open-angle glaucoma in diabetes patients: A Korean nationwide cohort study Na, Kyung-Sun Kim, Jin-Ho Paik, Ji-Sun Cho, Won-Kyung Ha, Minji Park, Yong-Gyu Yang, Suk-Woo Medicine (Baltimore) 5800 The impact of underweight on the risk of developing primary open-angle glaucoma (POAG) is not known, although the association between obesity and POAG has been well studied. We evaluated the risk of POAG among underweight patients by studying a nationwide cohort sample in South Korea. We analyzed data from the Korean National Health Insurance Research Database collected between 2009 and 2012 for 17,000,636 patients aged 40 years or older. Newly diagnosed POAG in the cohort was identified using claims data between 2009 and 2015. A total of 442,829 individuals (2.60%) were classified as underweight (body mass index [BMI] < 18.5 kg/m(2)). During the follow-up period, 435,756 (2.56%) subjects were newly diagnosed with POAG. Multivariate analyses revealed that underweight was significantly related to an increased risk of future POAG development, by 9.8% and 27.8% in individuals with and without diabetes, respectively. There was a reverse J-shaped relationship between BMI and risk of POAG in the normal, impaired glucose tolerance, and diabetes groups; especially, this relationship was most notable in participants with diabetes. Patients who were underweight exhibited a significantly higher prospective risk of POAG, even after adjusting for confounding factors. Wolters Kluwer Health 2020-03-06 /pmc/articles/PMC7478655/ /pubmed/32150063 http://dx.doi.org/10.1097/MD.0000000000019285 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5800 Na, Kyung-Sun Kim, Jin-Ho Paik, Ji-Sun Cho, Won-Kyung Ha, Minji Park, Yong-Gyu Yang, Suk-Woo Underweight increases the risk of primary open-angle glaucoma in diabetes patients: A Korean nationwide cohort study |
title | Underweight increases the risk of primary open-angle glaucoma in diabetes patients: A Korean nationwide cohort study |
title_full | Underweight increases the risk of primary open-angle glaucoma in diabetes patients: A Korean nationwide cohort study |
title_fullStr | Underweight increases the risk of primary open-angle glaucoma in diabetes patients: A Korean nationwide cohort study |
title_full_unstemmed | Underweight increases the risk of primary open-angle glaucoma in diabetes patients: A Korean nationwide cohort study |
title_short | Underweight increases the risk of primary open-angle glaucoma in diabetes patients: A Korean nationwide cohort study |
title_sort | underweight increases the risk of primary open-angle glaucoma in diabetes patients: a korean nationwide cohort study |
topic | 5800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478655/ https://www.ncbi.nlm.nih.gov/pubmed/32150063 http://dx.doi.org/10.1097/MD.0000000000019285 |
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